PHYSIOLOGY: KLEINER AND MELTZER 
371 
considerably the elimination through the kidney of intravenously in- 
jected sugar, and increases moderately the volume of the secreted urine. 
In these various series of experiments also the sugar content of the 
blood was tested and compared with one another. Tests were made 
before the intravenous injection of sugar and at the end of it, and thirty 
minutes, sixty minutes and ninety minutes after the end of the injection. 
The results were in a certain sense opposite to those observed for the 
urine. The averages for six morphinized dogs were as follows: 0.24% 
before the injection, 0.99% at the end, 0.57% after thirty, 0.41% after 
sixty and 0.32% ninety minutes after the end of the injection. The 
average for six non-morphinized dogs (dextrose in water) were: 0.16% 
before the injection, 0.6% at the end, 0.19% after thirty, 0.16% after 
sixty and 0.16% ninety minutes after the end of the injection. These 
data mean that in morphinized dogs, after intravenous injection of 
dextrose, the sugar content of the blood returns to the normal level much 
slower than in non-morphinized dogs. 
However, in consideration of the fact that morphin alone causes a 
moderate hyperglycaemia (with a very slight glycosuria) two experi- 
ments were made on non-morphinized dogs which had at the start a 
hyperglycaemia. These animals received intravenously one gram of 
dextrose per kilo, which brought the glycaemia to 0.35%; then four grams 
more per kilo were injected. At the end of this injection the hyper- 
glycaemia was 0.45%; thirty minutes after the end, about 0.16%; 
after sixty minutes, 0.15%; and after ninety minutes, 0.15%. This 
shows that without morphin the sugar of the blood returns more rapidly 
to the normal level even when the intravenous injection of four grams of 
sugar per kilo is started while the sugar content of the blood is temporarily 
on a level higher than that due to morphin. The ehmination of sugar 
in the urine amounted to about 18.5% of the entire quantity of the 
injected sugar. 
Our experiments show the following facts. 1. Morphin, in the dose 
employed in our experiments, increases considerably the ehmination 
through the kidneys of intravenously injected dextrose, although the 
increase in the volume of secreted urine is comparatively moderate. 
Without morphin the elimination of sugar is comparatively small even 
if the volume of the secreted urine is considerably increased by the 
addition of sodium sulphate to the intravenously injected dextrose. 2. 
Morphin retards the return of the sugar content of the blood to its pre- 
vious level. The originally slightly higher level of glycaemia which is 
produced by morphin itself does not seem to be responsible for either 
the slow return of the glycaemia or for the greater ehmination through 
the kidney. 
