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PHYSIOLOGY: KLEINER AND MELTZER 
the end of the dextrose injection, was at least twice as high as that of the 
sample taken before the injection. Apparently the removal of the pan- 
creas interfered with the power of the circulation to rid itself readily 
of a surplus of dextrose. The possible ability of the Hver to provide 
the circulation with a greater supply of dextrose in the absence of the 
pancreas can certainly be no important factor in these results. Our 
experiments show, then, that in the presence of the pancreas the circulation 
rids itself easily of intravenously introduced dextrose; hut that it is unable 
to do it satisfactorily in the absence of the pancreas. On the basis of these 
facts is it not plausible to assume further that the pancreas exerts exactly 
the same influence, when the dextrose in the circulation is being supplied 
in some other manner than by a burette into a vein, for instance, by the 
liver through its connections with the circulation? Or, in other words, 
do not our experiments make the assumption plausible that pancreatic 
hyperglycaemia is due to the fact that in the absence of the pancreas the 
circulation is unable to dispose properly of the dextrose which it receives 
in normal amounts from the liver? 
In a third series, the experiments were again made by injecting dex- 
trose intravenously in depancreatized dogs. But in these cases a strained 
pancreatic emulsion was added to the dextrose solution, and in some 
instances the infusion of the pancreatic emulsion was continued for 
some time after the infusion of the dextrose was finished. We present 
here merely a preliminary communication; we have not yet mastered 
all the details of this part of the investigation. But there seems to be 
no doubt about the nature and validity of the main result, which is 
this: In such experiments, ninety minutes after the end of the dextrose 
infusion, the dextrose content of the blood is again at about the same level 
as it was before the infusion of the dextrose. Apparently the presence of 
a pancreatic emulsion within the blood helps the circulation to get rid 
of the surplus of dextrose injected intravenously. In these experiments 
it is evident that the effect of the pancreas can be only of a chemical and 
not of a nervous nature, or, in other words, it is the internal secretion 
of the pancreas which helps the circulation to get rid of the surplus of 
dextrose. 
To the above results we wish now to add the following preliminary 
statement derived from three experiments. In depancreatized animals 
the blood of which has shown a marked hyperglycaemia, an intravenous 
infusion of a pancreas emulsion brought the dextrose content of the blood 
to 0.09% and even 0.08%. The hyperglycaemia returned next day and 
could be reduced again to the normal level by an infusion of pancreas 
emulsion . 
