Addison, on Blood-corpuscles. 
23 
The following have been found to succeed in producing the 
tailed forms of corpuscles (fig, 4) : 
1. Sherry wine. 
2. Sherry wine and saline solution. 
3. One part fresh urine and two or three parts sherry wine. 
4. Port wine and quinine. — Dissolve with a gentle warmth 
one grain of sulphate of quinine in half a fluid ounce of port 
wine ; set it by for two or three days, and then filter the 
liquid. 
5. A mixture of the sherry wine and the saline solution 
with port wine and quinine. — This mixture seems to improve 
by keeping. 
The following experiments have been tried : 
1. One fluid drachm of the mixture No. 5 and one grain 
of sulphate of strychnia, shaken together. — Tails produced. 
2. One fluid drachm of No. 5 and one grain of acetate of 
morphia. — Tails produced. 
3. One fluid drachm of No. 5 and liquor potassse, just suf- 
ficient to remove the acid reaction of the mixed wines. — No 
tails appeared. 
In all these experiments there is no mixing together of the 
blood and the extraneous fluid previous to the application of 
the covering-glass, hence there are various degrees of inter- 
mingling between the added fluid and the natural fluid of the 
blood, and it is only where these two fluids are mixed in cer- 
tain unascertainable proportions that the specific phenomena 
'are to be seen. 
Blood consists of a fluid — the liquor sanguinis — and the cor- 
puscles ; therefore, before arriving at any conclusion from the 
preceding experiments, it will be necessary to consider the 
part played by the fluid element of the blood. The added 
fluids, when they come, undiluted by the liquor sanguinis, 
into contact with the red corpuscles, destroy them. The 
changes of form of the corpuscles are therefore eff'ected, not 
by the extraneous or added fluid alone, but by a mixture of the 
added liquid and the liquor sanguinis ; and we conceive it to 
be correct to regard the phenomena described as the results 
of a change in the quality of the liquor sanguinis, wrought by 
the added liquor. It is to an unascertained mixture of the 
extraneous fluid and the natural blood-fluid that the various 
aspects of the corpuscles must be ascribed. It is well known 
how speedily elements of diet, medicinal substances, and poi- 
sons, are found in the liquor sanguinis, and these experiments 
show that corpuscles which have been changed in their form 
from change in the quality of the liquor sanguinis may be 
altered back again to their normal form by a counteracting 
