— 99 — 
The high prices have brought many old speculative stocks to the 
light in Europe, which were frequently sold below the market-price. 
On account of the slight solubility of menthol and peppermint oil 
in water, it is often necessary to have recourse to high-priced alcoholic 
solutions. Dr. Cresantignes ^) therefore proposes to dissolve menthol 
first in tincture of quillaia, and to add this solution to the water in 
small portions. It is stated that in this manner clear and permanent 
menthol-mixtures can be obtained, for example: — 
Menthol 0,15 to 0,3 g 
Tinct. quillaiae . . . . . 10,0 „ 
Aq. qu. s. ad 150,000. 
The following prescription is given for a mouth-wash: — 
Menthol. ..... 0,1 to 0,2 g 
Tinct. quillaiae 20,0,, 
Solut. acid, boric, i per cent. 1 000,0 „ 
For internal use the mixtures may perhaps not be suitable, on ac- 
count of the toxic properties of the quillaia-tincture. 
Safrol. Nothing can as yet be noticed of the competition of the 
Japanese product, which some while ago was announced with such a 
great flourish; it appears that wise counsels have prevailed, and that 
the enterprise has been abandoned during the last few months, rather 
than let it come to a fiasco. The article is of too little importance 
than that its production, carried on as a separate industry, could be 
made remunerative. We push this article, and meet every competition 
where it is a question of a product of equal value. 
Amyl ester of Salicylic acid. This preparation, of which we 
have taken up the manufacture some time ago, has found a large and 
varied application in the perfumery-industry. Lately it has also come 
into use for therapeutic purposes^). According to Doyen and Chanoz 
the ester is only slightly poisonous, and splits up in the liver into 
amyl alcohol and salicylic acid. Lyonett dressed rheumatic affections 
with 2 to 3 g of the ester, by means of cotton-wool and gutta-percha 
tissue. No inflammation was ever observed. He always found after- 
wards that the pain and swelling had abated, but never that the 
remedy was not tolerated. Salicylic acid can within a short time be 
detected in the urine. When administered internally good results are 
also obtained. 
^) Rep. de Pharm. 1903, Nr. i. According to Pharm. Ztg. 48 (1903), 78. 
^) According to Pharm. Centralhalle 43 (1902), 637. 
