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Experiment No. 2. A frog of 40 g weight received 0,05 g methyl ester of 
acetyl anthranilic acid in emulsion with olive oil. Only after 2 hours the 
dorsal position was tolerated, and the reflex-actions commenced to grow more 
feeble. After 18 hours reflex-action could no longer be produced. The heart 
beat slowly and faintly. After 28 hours, on stimulation, the first faint reflex- 
actions again became noticeable; in the course of the day they grew stronger. 
After 3 times 24 hours the frog had so far recovered that it no longer tolerated 
the dorsal position. 
Experiment No. 3. A frog weighing 28 g (which appeared to be some- 
what exhausted already before the experiment) received a subcutaneous in- 
jection of 0,04 g of the acetyl compound. After ^/^ - hour the dorsal position 
was tolerated without the slightest resisting movements. The reflex-action was 
still good, but disappeared completely already after 2^1^ hours. The action of 
the heart after 16 hours was scarcely perceptible. Death occurred after about 
70 hours. 
Section: Cavity of the mouth, and also the mesentery, moderately in- 
jected. The stomach and intestine were strongly hyperoemic, but without 
extravasation of blood. 
Experiment No. 4. A frog w^heighing 30 g received an injection of 0,04 g 
methyl ester of acetyl anthranilic acid. An hour later the frog was still per- 
fectly healthy, but after 2 hours it was no longer able to turn over on the 
abdomen. The reflex-action even after 3^/^ hours was still normal. In the 
dorsal position some faint swimming movements were made. Respiration 
was superficial, but had not become slower. The reflex - action gradually 
decreased, and ceased after 38 hours. Death occurred after 4 X 24 hours. 
Section: The cavity of the mouth, and the stomach and intestine, were 
slightly injected. A completely-filled gallcyst of 1,4 cm diameter, whose walls 
were also slightly injected, was situated on the liver. 
Experiment No. 5. A frog weighing 31 g was injected with 0,02 g of 
the acetyl compound. After 45 minutes the animal felt somewhat feeble, and 
after I'^j^ hours no longer resisted the dorsal position. In that position it 
made some inco - ordinate movements. Slight swimming movements in the 
dorsal position were made after 3^4 hours. At this time the respiration be- 
came slower and more superficial, but it became again normal after 21 hours. 
Recovery progressed but slowly. After 3 X 24 hours the frog was found in 
a sitting posture, and appeared to be healthy, but, when placed in the dorsal 
position, it could not turn over on its abdomen in spite of all efforts. During 
the whole time the action of the heart had remained good, and the reflex-action 
had not diminished. 
Experiment No. 6. The same dose was given to a frog of 27 g weight. 
After 45 minutes it could only turn over with difficulty from the dorsal to 
the abdominal position. Reflex-action had disappeared already after 2 hours. 
The action of the heart which grew increasingly feeble, again became stronger 
after 18 hours. When stimulated, a slight reaction also became again noticeable. 
After 3 X 24 hours the frog, like the one in experiment No. 5, appeared to 
be in a healthy state when in the abdominal position. When turned on its 
back, it suddenly breathed very rapidly and deeply. The extremities, especially 
those in front, thereby showed slight clonic and tonic spasms. A complete 
recovery only occurred after 4 X 24 hours (from the time of injection). 
Experiment No. 7. A frog weighing 42 g received a dose of 0,1 g of 
the substance. When after ^/^ hour the reflex-action had ceased, it made 
some isolated inco-ordinate movements. After 1 8 hours it was found dead. 
Experiment No. 8. The same dose was given to a frog weighing 63 g. 
45 minutes later, when it was absolutely without reaction, an injection was 
made with 0,00006 g strychnine nitrate. The action of the strychnine became 
