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rhombic prisms. In transmitted light the prisms are partly light-brown, 
partly black coloured. 
If to an aqueous solution of methyl ester of acetyl methyl an- 
thranilic acid, after the addition of Florence- solution, soda liquor is 
added, the precipitate dissolves with a bright-yellow colour, and is 
not formed again even when an excess of hydrochloric acid is added. 
On the other hand, there is formed, either immediately, or, in case 
of insufficient concentration, in the course of 24 hours, an abundant 
precipitate of delicate sharp needles, which in transmitted light have 
a greenish-blue, and in reflected light a green-black colour. In hot 
water and in dilute soda liquor they dissolve immediately, but are 
again precipitated after the addition of hydrochloric acid. 
With potassium ferricyanide and ferric chloride the acetyl com- 
pound does not form a blue precipitate. 
A short time ago the makers succeeded in producing the acetyl 
compound of methyl ester of methyl anthranilic acid in crystalline 
form, instead of the amorphous mass hitherto obtained. The pre- 
paration placed at my disposal consisted of small crystals, which 
liquefied into an oil on being slightly heated. Treated with Florence- 
solution they formed a precipitate only when a small quantity of 
hydrochloric acid was added, but this precipitate did not crystallise 
out. After adding soda and hydrochloric acid the above-mentioned 
crystalline needles were precipitated. 
For the following experiments on animals with the acetyl com- 
pound of methyl ester of methyl anthranilic acid, the form in which 
the compound was used was always that of aqueous solutions of the 
first consignment, except in those cases where the remarks show that 
either the pure substance was employed, or else aqueous solutions of 
the second consignment. 
Experiment No. i. A frog weighing 53 g received 0,0458 g. After 
25 minutes it reacted but little. The action of the heart remained good. 
After 18 hours the frog was found to be again quite healthy. 
Experiment No. 2. A frog weighing 60 g received 0,06 g. After 
30 minutes the reflex-action was only feeble. Complete absence of reaction 
was observed after 4 hours, but the heart acted powerfully. After 24 hours 
the animal had made fair progress towards recovery. 
Experiment No. 3. A frog weighing 60 g, 15 minutes after injection of 
0,09 g, tolerated already the dorsal position; reflex -action was only faintly 
indicated, and ceased completely shortly afterwards. The action of the heart 
diminished gradually, and was subsequently hardly perceptible. The first 
slight reflex-action was again obtained after three times 24 hours; it increased 
a little in the course of the fourth day, but had again ceased after 104 hours 
(after injection). On the abdomen, and especially on the lower part of the 
throat and mouth, and also on the axillary and inguinal regions, and the lower 
part of the upper thigh, there appeared on the third day a few papillae varying 
in size from that of a poppy-seed to a millet-grain, and having a reddish-yellow 
colour. After five times 24 hours the frog was found dead, but not rigid. 
