hour, it turned over a few times as if about to wake up. In the course of 
5 hours it had completely recovered, and took food. 
Experiment No. 9. A full-grown medium-sized rabbit received 0,55 g sub- 
cutaneously. The animal soon became feeble, and after half an hour sat down 
quietly. When laid on the back, it regained its feet only slowly. The reflex- 
actions, respiration, and pulsation were not reduced. After 3 hours it had re- 
covered fairly well. 
This rabbit died suddenly 5 weeks afterwards. The internal organs, with 
the exception of the stomach, were found to be normal. But at the pylorus 
several ulcers were found, varying in size from a pin's head to the size of a 
lentil, and of a black -brown colour. A piece of the stomach was embedded 
in paraffin and stained. Examined under the microscope, it was found that 
the ulcers did not penetrate into the submucosa, but that only the mucous 
membrane was ulcerated. It was a remarkable fact that blood or blood-pigment 
could not be detected microscopically at the transverse sections. 
It may be assumed that these ulcers were connected with the sudden 
death of the animal, but it is doubtful whether there exists any connection 
between the injection of the acetyl compound of methyl ester of anthranilic 
acid, and the presence of the ulcers in the stomach. 
Experiment No. 10. A small dog weighing about 5 kilograms received a 
subcutaneous injection of i cc of the pure undiluted substance. The animal 
remained healthy. 
Experiments No. 11 and 12. The samiC dog remained in good health after 
being injected with 1,2 g of the substance in dilution, and 1,8 cc of the un- 
diluted substance. 
All the specimens of urine formed with Florence- solution a brown precipi- 
tate, which, however, did not crystallise out. After adding soda liquor and an 
excess of hydrochloric acid, the characteristic needles were never precipitated, 
neither immediately, nor subsequently. 
The urine of the guinea pig, which possessed an aromatic odour, was 
repeatedly treated with Florence- solution, and each time extracted with ether 
in which the precipitate dissolved. After driving off the ether, the residue 
was heated on a water bath until iodine was no longer sublimed, and it was 
then absorbed with a small quantity of water. After one week a few druses 
had crystallised out, which with potassium ferricyanide and ferric chloride formed 
a blue precipitate. They resembled the crystals mentioned on page 123. 
The urine of the two rabbits had a strong characteristic odour and was 
free from albumin , but after adding soda liquor it possessed a very powerful 
reducing-action on copper sulphate, even when the temperature was but slightly 
raised. At first bright - yellow protoxide hydrate was formed, then red prot- 
oxide of copper. Salts of silver and of gold were also reduced. 
As the presence of sugar was suspected, a portion of the urine of the 
rabbit which had received 0,55 g of the acetyl compound of methyl ester of 
methyl anthranilic acid (comp. experiment No. 9), was fermented with yeast. 
The sugar test gave positive results, the quantity of sugar found being 0,6 
per cent. 
The remaining portion of the urine was treated in the same manner as 
that of the guinea pig. After one week small druses and verruciform and 
fascicular crystals were found on the bottom of the vessel. 
The urine of the other rabbit was treated with sulphuric acid until it 
had a pronounced acid reaction; it was then evaporated to the consistency of 
syrup, again rendered alkaline, and extracted with ether. The ethereal extract 
showed a blue fluorescence. After adding a few cc water, the ether was 
driven off, and there were then floating on the water a few oil-drops of a 
yellowish colour. One of these was removed with a spatula, the spatula round 
