— 8i — 
toxic symptoms which showed no noticeable difference in their effect 
and intensity. Cyclogeraniol behaved differently; this only produced 
a state of deep stupor when administered in a dose four times as large. 
The administration of geraniol and citral to rabbits yielded, as a 
first and principal product of assimilation, a dibasic acid^) Cjo^i4^4 
of the melting point 192° to 194°, for whose constitution the formula 
may be accepted as the most probable one. Cyclogeraniol and cyclocitral 
did not yield this acid, but only combined glycuronic acids were de- 
tected in the urine of the animals. When nerol was administered, 
abundant quantities of glycuronic acids could also be detected, in 
addition to small quantities of the dibasic acid, whose presence can 
be explained by the geraniol-content of nerol. According to these 
experiments the author considers nerol a body differing from geraniol. 
H. Winterberg2) makes some communications on experimental 
examinations of the effect of camphor on the heart and on the vessels 
of mammals. According to these, camphor, when introduced direct into 
the circulation, exerts a transitory stimulating action on the vasomotor 
centre, which manifests itself in a transient, unimportant increase in 
the pressure of the blood. But as the principal action on the vessels, 
a peripheral vascular dilatation with diminished pressure of the blood 
was observed. Camphor does not promote the action of the heart, 
but neither have small and medium doses any injurious effect on it. 
Jakobj^) has studied the pharmacological action on frogs and mice, 
of the following cyclic isoximes and of some compounds closely related 
to the latter: pentanone, hexanone, pentanone isoxime, hexanone isoxime, 
methyl pentanone isoxime, a- and /?-methyl hexanone isoximes, laevo- 
menthone isoxime, tetrahydrocarvone isoxime, bihydrolaevomenthone 
isoxime, benzoyl bihydrolaevomenthone isoxime, isofenchone oxime, 
thujamenthone isoxime, trimethyl cyclohexanone isoxime. It was thereb}' 
found that all cyclic isoximes, if they produce any effect at all, belong 
to the group of medullary spasm-toxins represented by picrotoxin and 
camphor. All other compounds without the CO- or CH-group in the 
^) Arch. f. experim. Pharm. u. Path. 45 (190 1), 121. Report April 1902, 84. 
2) Pfliiger's Arch. 94, 455. Report Chem. Centralblatt 1903, I. 848. 
^) Nachr. K. Ges. Wiss. Gottingen 1902, 313. Report Chem. Centralblatt 
1903, I. 1092. 
C = CH — CH2 — CH = C — CH2 — COOH 
COOH 
6 
