— 123 — 
10. Group of Leukotactics. 
As indirect antiseptics, or leukotactics, I desire to discuss a group 
of substances which effect a ''healthy leukocytosis'', and which send 
forward the increased number of white blood - corpuscles occurring 
in that process as combatants against the toxic substances and the 
invading microbes. The first experiments on the action of essential 
oils on the number of leukocytes circulating in the blood, originate 
from E. Hirt (1856) and from C. Binz and his pupils H, Meyer 
and V. V. Grisar. In addition to these, I have made (at first still 
under H. Koehler), partly alone, partly with S. D. Marcusson^). 
and with Bohm^), counting tests of the most primitive character with 
the blood of animals to which essential oil had been administered. 
The experiments made by R. Winternitz^) are greatly perfected in 
their technique. According to all the above-mentioned authors, most 
essential oils or their components (excepting menthol and camphor), 
produce leukocytes, and that with subcutaneous injection in the first 
instance locally (so-called sterile suppuration). Attempts have been 
made to utilise this, for example with oil of turpentine in appen- 
dicitis^). Too large doses of this oil, however, when repeatedly ad- 
ministered, produce amyloid degeneration. H. Schulz^) andBrummer, 
on the other hand, go much too far when they think they have 
observed on themselves all sorts of disturbances after merely fractions of 
one drop of turpentine oil. In France, Tinctura thujae is used as a leuko- 
tactic remedy. 
The leukotactic action of Balsam of Peru led Landerer to the 
introduction of injections of this substance into the blood as a remedy 
against tuberculosis. Later on, this investigator passed from the balsam 
to the active substances of the latter and, as is well known, now con- 
tinues these injections, not without favourable result, with chemically 
pure compounds of cinnamic acid. It is impossible to quote the very 
large number of publications which exist on this subject. — Finally 
I would briefly mention the Peru cognac, or "perco", much advertised 
as a remedy against tuberculosis. 
11. Group of Antiparasitics. 
It is advisable to divide this group, which attack animal parasites, 
into two subdivisions, viz., external and internal. 
1) Das Pfefferminzol, Thesis, Halle 1877. 
-) Compare citation on. ^age 115. 
liber Allgemeinwirkung ortlich reizender Stoffe. Arch. exp. Path. u. Pharm. 
35 (1895), 77. 
^) Moritz Mayer, Erfahrungen iiber Terpentinol und verwandte Mittel bei 
Blinddarmentziindung. Miinch. med. Wochenschr. 1902, No. 32. 
^) Ein Beitrag zur Kenntnis der Terpentinolwirkung. Miinch. med. Wochenschr. 
1900, No. 28. 
