MALARIA EXPEDITION TO NIGERIA 
265 
Duodenum and Small Intestine were stained a dull, greyish-brown colour. About 
nine inches from duodenum to a few inches from the coecum, the gut con- 
taining frothy, blackish-brown, mucous material staining the mucous 
membrane. No petechial nor haemorrhagic spots. Mucous membrane 
otherwise normal. 
Coecum and large Intestine appeared normal. 
Suprarenals and Bladder — normal. 
Thorax — No pleuritic fluid — slight old adhesion at the base of the right lung. No 
periodical fluid. 
Heart — Left ventricular wall hypertrophied. Cardiac muscle firm. Valves 
healthy. Slight early atheroma of the aorta just above the valves. 
Lungs — Some old pigmented fibroid patches at both apices. Patch of old pleuritis 
at right base adhering to the diaphragm. Bronchi contained a quantity 
of yellowish muco-pus. This condition extended down to the small 
bronchioles. On section of the lung, muco-pus welled from numerous 
points. No broncho-pneumonia. No hypostatic congestion. 
Oesophagus — Normal. 
Trachea — Contained a little muco-pus. 
Epiglottis — Two very small ulcers at the base size of pinhead. 
Pharynx and Thryroid Gland — Normal. 
Brain — Rather wet and oedematous, firm, otherwise appeared normal ; numerous 
small pachionian bodies. 
Morbid Histology 
Liver — Sections of the liver present very little pathological change. There is a 
slight increase of fibrous tissue around the portal canals, with a slight 
thickening of ' Glysson's ' capsule. Slight congestion of the hepatic zone. 
The liver cells are sharply defined — the nucleus staining well with 
Haematein, the cell protoplasm shews a very slightly granular appearance. 
Slight fatty infiltration occurs in the portal zones of some of rhe liver 
lobules. Marked yellow pigmentary deposit is observed in the liver cells 
throughout the whole lobule. No recent malarial pigment can be made 
out in the capillary endothelial cells, and traces of old pigment are only 
very occasionally seen. The liver cells throughout the lobules give a 
marked reaction of iron with pure haematoxylin, and with potassium 
ferrocyanide and hydrochloric acid. 
Spleen — Sections shew an increase of fibrous tissue. The trabeculae are thickened 
and the splenic pulp appears overgrown with fibrous tissue. The small 
arteries of the Malpighian corpuscles, which are inconspicuous, are greatly 
thickened both throughout their internal and external coats. The splenic 
capsule is thickened. Malarial pigment only occurs at very rare intervals 
throughout the sections. With ferrocyanide of potash and hydrochloric acid, 
and also with pure haematoxylin no very marked iron reaction is brought out. 
Masses of haematoidin pigment were scattered throughout the sections. 
