10 
THOMPSON YATES LABORATORIES REPORT 
Table I 
Typhoid. 
Cholera. 
Coli 
(^Normal ... 
Normal ... 
Normal ... 
Phthisis ... 
Diabetes ... 
Lead poisoning 
Empyema 
Pleural effusion 
Atheroma 
Hemiplegia 
Normal 
Perityphlitis 
Leucocythaemia 
Normal 
.Normal . . . 
^Fourth day 
Sixth day ... 
Sixth day . . . 
Sixth day ... 
Seventh day 
Eighth day 
Tenth day 
Thirteenth d.ay 
Not I to 
Signs I to 5 
Not I to 5 
Not I to 5 
_ I to 5 
Signs I to 5 
I to lo 
Not I to 5 
I to lo 
Not I to 5 
I to 6o 
I to 30 
I to 120 
Not I to 5 
I to 120 
Not 1 to 5 
Not I to 5 
Signs I to 5 
Not I to 5 
I to 10 
Not I to 5 
Not 1 to 5 
I to 30 
I to 120 
I to 60 
I to 30 
1 to 60 
I to 30 
I to I2C 
I to 200 
Not I to 20 
I to 60 
I to 30 
I to 120 
At the dilutions given the action was not pronounced negative until after two hours. At such 
small dilutions as i to 20 the coli organism was agglutinated within 20 minutes with precisely similar 
appearances to those seen in the agglutination of the typhoid bacillus. 
was one which gave in a marked degree the characters of the B. coli, such as.indol formation, 
coagulation of milk, gas formation, marked growth on potato, etc. 
In order to see to what extent this action would hold good with different varieties of colon 
Bacillus, I tried the action of normal and typhoid sera in dilution upon 16 cultures of supposed 
coli organisms taken from different sources. Three of these were acting pathogenically, 4 were 
from sewage, 4 from milk, 3 from mussels, and i from cheese. 
It will be seen that the majority of these were agglutinated by human serum, independently 
of the fact whether it was from a typhoid patient or not. In fact, had any of these been suspected 
typhoid organisms, and the action of human typhoid serum been tried upon them, they might 
very easily have been returned as typhoid bacilli. 
In face of these results, I think that in the use of human typhoid serum for diagnosing 
suspected typhoid bacilli found in water, milk, etc., the equally specific action of the serum upon 
B. coli must also be borne in mind. 
In the examination of a number of rabbits' sera I found that, in the majority of cases, 
dilution to the extent of i in 20 did away with all agglutinating action upon both the typhoid and 
