24 
THOMPSON YATES LABORATORIES REPORT 
experiments have given negative results. So far as I can ascertain the organism isolated has not 
been described before. 
Further examinations of the blood have failed to detect any organisms, and, taking into 
account the failure of the inoculations, it is evident that this organism has nothing to do with 
lymphadenoma. At the time it was present the patient was undergoing a febrile attack, no doubt 
due to the Staphylococcus albus infection. 
Before considering the question of the bacteriology of Hodgkin's disease, it is necessary to 
point out the confusion which exists with regard to the exact application of the term lyphadenoma. 
This is well shown in the list of names given by Von Limbeck* under the generic term — 
Pseudo-leukaemia : (Hodgkin's disease), anaemia lymphatica (Wilks), cachexie sans leucemie 
(BoNFiLs), adenie (Trousseau), anaemia splenica (Griesinger), malignes lympho-sarcom 
(Langhans), malignes lymphom (Billroth), desmoid carcinom (R. Schulz). 
It is, I believe, not yet possible to draw sharp lines between the conditions which are 
mustered under the title of pseudo-leukaemia, but it seems probable that it includes more than one 
disease. 
Taking the condition from a general point of view, it has of late years been more and 
more frequently urged that it is of an infective nature, on the score of (i) the anatomical structure 
of the enlarged glands, and the deposits in the various organs ; (2) the symptomatic features, 
anaemia, haemorrhages, and so forth. 
On looking up the literature, the investigations of the disease from the infective point of 
view have not been numerous. KLEBst states that Weigert found bacilli having the staining 
characteristics of tubercle bacilli in the enlarged mesenteric glands, and that he himself in one case 
found a short, freely motile bacillus in the blood, both during life and post-mortem. Kelsch and 
VaillardJ in a case of ' Tumeurs lymphadeniques multiples avec Leucemie,' found once during 
life and in the organs after death a short non-motile bacillus, hardly longer than broad, staining 
readily with methylene-blue, but not by Gram's method. It did not liquefy gelatine, and on 
potato at 35° C. gave a moist shining yellowish-brown growth. Inoculations into Guinea-pigs 
gave no results, but Rabbits and white Mice were killed in 36 hours. They do not claim specific 
properties for this organism. 
Dreschfeld§ Iras put on record a case of acute Hodgkin's disease, in which small bacilli 
were found in the kidney post-mortem. Cultivations were not obtained. Traversa || has 
recorded a case of acute pseudo-leukaemia, in which streptococci were found in the blood during 
life, and GrossiII a similar case, in which the examination had a negative bacteriological result. 
Lannois and Groux** have recorded a case of acute pseudo-leukaemia in which Staphylococcus 
pyogenes aureus was found. 
It may fairly be assumed that, in my case and in those of Traversa, Lannois, and Groux, 
* Von Limbeck. 'Klin. Path, ties Blutes,' 2 te Aufl. S. 326. 
-|- Klebs. ' Allgemeine Pathologic' 
J Kelsch and Vaillard. 'Ann. de I'lnst. Pasteur,' Paris, 1890, 
tome iv, p. 276. 
§ Dreschfeld. ' Brit. Med. Journ.,' London, 1892, vol. i, p. 893. 
II Traversa. ' Riforma med.,' Napoli, 1893, t. ix, 
p. 26. 
Grossi. Ibid., 1893, t. ix, p. 62. 
** Lannois and Groux. ' Lyon med.,' 1890, No. 34. 
