THE MORBID ANATOMY AND PATHOLOGY 
OF DR. BRADSHAW'S CASE OF MYELOPATHIC ALBUMOSURIA* 
By THOS. R. BRADSHAW, B.A., M.D., M.R.C.P , Senior Assistant Physician to the 
Liverpool Royal Infirmary 
AND 
W. B. WARRINGTON, M.D., M.R C.P., Demonstrator of Pathology in University 
College Liverpool, Assistant Physician to the Hospital for Consumption 
AND Diseases of the Chest 
Plate XIII 
On the 26th of April, 1898, one of us (Dr. Bradshaw) read before this society an 
account of a case in which the urine contained a very large quantity of a form of proteid, which 
was shown by its chemical reactions to be related to the class of bodies known as albumoses.t 
The main facts of the case which were then reported, and its subsequent history until the death of 
the patient, were briefly as follows. 
A man 70 years of age, a respectable shopkeeper in Liverpool, noticed about the end of the 
year 1896 that he passed milky urine from time to time. In August, 1897, systematic examinations 
of the urine were instituted, and it was found that it always contained a large but variable amount 
of a proteid body which was coagulated by a temperature below 60° C, and yielded other 
reactions which served to identify it with the peculiar albuminous body which was first described 
by Bench Jones in 1847, and is now commonly known as albumose.J 
Beyond the fact of the presence of this remarkable body in the urine there was at first 
nothing to suggest that the patient was the subject of any serious disease. All the ordinary 
indications of renal disorder were wanting, and for some months there was nothing in his 
circumstances or condition which afforded any clue to the significance of the remarkable condition 
of the urine. An examination of the literature, however, showed that the kind of albumosuria 
described by Bence Jones had been observed in six cases in all, and that in every instance it had 
been found to be associated with an affection of the bones of the trunk. This affection had been 
at first regarded as a form of osteomalacia ; but the more recent observers had found that it was a 
form of multiple myeloma, a disorder in which the bones undergo absorption, and become 
attenuated in consequence of the development of a new growth which originates in the marrow 
* Reprinted from the ' Medico-Chirurgical Transactions,' vol. Ixxxii. 
t T. R. Bradshaw. 'A Case of Albumosuria in which the Albumose was spontaneously precipitated.' 'Med.-Chir. Trans., 
1898, p. 259. 
J Bence Jones. 'On anew Substance occurring in the Urine of a Patient with Mollities Ossium.' 'Phil. Trans, of the Royal 
Society,' 1848. 
