82 
THOMPSON YATES LABORATORIES REPORT 
vertebra, and of the sternum, some of the gelatinous marrow-like substance in the sternum, and 
pieces of kidney. 
On the same day some of the fresh marrow-line substance was extracted with a weak 
sodium chloride solution. The extract gave a marked albumose reaction with nitric acid and 
a turbidity with hydrochloric. Unfortunately the rest of the marrow-like material was by 
inadvertence placed in weak formalin solution, with the result that the proteids were rendered 
insoluble, and so their coagulation points could not be taken. As far as it went, the evidence 
pointed to the soft material in the bones containing the same substance as was found in the 
urine. 
The piece of rib exhibited, preserved in formalin, shows that the bone is reduced to a mere 
shell about the thickness of notepaper, but its general outline is preserved. The interior is 
occupied by soft material, which, in the fresh state, was a bluish-red semi-solid pulp, which had 
taken the place of all except the most superficial parts of the bone (PI. V, Fig. i). 
A small piece of rib, freed as far as possible from periosteum and other soft material, and 
dried in an incubator, was sent to Mr. Collingwood Williams, the Liverpool City Analyst, who 
kindly undertook the analysis of it for us. 
His report is as follows : — 
The quantity available for analysis was O'liJ gramme. 
Organic matter ... ... ... 45*85 per cent. 
Mineral ... ... ... ... 54' 1 5 „ 
100*00 „ 
DESCRIPTION OF PLATE XIII 
Fig. I. A portion of an affected rib near its cartiLige. To the right is seen the cartilage in transverse 
section ; to the left is seen the thin shell of bone, part of which has been removed so as to 
show the contained mass of new growth, which has shrunken somewhat and appears dark. 
(Near/y natural size.) 
Fig. 2, Transverse section of decalcified rib. The osseous tissue is greatly reduced in thickness, and is 
being invaded by the new growth which is seen in situ. ( Zeiss, obj. A without ocular.) 
Fig. 3. Section of new growth in interior of sternum. The general characters of the structure are those 
of a round-celled sarcoma. (\ inch objective.) 
Fig. 4. The same as Fig. 3, more highly magnified, showing the cells of the growth in more detail. 
( Jpochromatic 3 mm. immersion objective, aperture 1.40, compensating ocular 12.) 
Fig. 5. The same as Fig. 4, another part of section. 
Fig. 6. Transverse section of decalcified bony shell of rib. 
(/) Inner aspect of shell, in contact with new growth which has become detached during 
manipulation. 
(e) External surface, with muscle attached. This section gave some evidence of a retrograde 
change in the structure of the bone, (i inch objective.) 
Fig. 7. Transverse section of superficial layer of decalcified sternum. 
(b) Internal surface of osseous layer, apparentl}- undergoing erosion. 
(») Fragment of new growth in situ. {Zeiss obj. A without ocular.) 
Fio. 8. Tangential section of dried bon)' shell of rib, prepared hy grinding. vShows normal disposition 
of lacunar and canaliculi. {Zeiss obj. A without ocular.) 
