CASE OF MYELOPATHIC ALBUMOSURIA 
83 
Composition oj ash : — 
Ca ... 36-63'] 
PO, ... 55-59 
Insoluble in HCl ... 5*10 
Not estimated ... 2"68 
Proportion of CaO, to P-O5 
5 : 4 
100-00^ 
If we make due allowance for the fact that no special precautions were taken to remove 
the fat, the proportion of organic to inorganic constituents does not depart greatly from the normal. 
Microscopical Examination 
The length of time which had elapsed since the death of the patient made the histological 
examination in some respects less satisfactory than we should have wished. 
A piece of rib was preserved in 4 per cent, formol solution, and portions of the gladiolus 
and vertebra in Muller's fluid. 
Thin slices of the dried bones were kindly prepared for us by Mr. J. A. Woods, L.D.S., and 
were mounted in Canada balsam. 
The gelatinous marrow-like substance, — This was studied by means of cover-slip preparations 
fixed with absolute alcohol and ether, and stained in various ways, viz., methylene blue, eosin, and 
logwood and eosin, and also in sections ; part of the material was fixed by saturated solution of 
perchloride of mercury, part in Muller's fluid, hardened in alcohol and embedded and cut in 
paraflRn. The sections were then stained by the above-named dyes, and also by picro-carmine and 
borax-carmine. 
The marrow-like substance was also studied in situ in sections of the bone which had been 
decalcified by means of a solution of phloroglucin in 5 per cent, nitric acid. 
By these means it was found that the cancellous spaces of the ribs, sternum, and vertebra 
were densely packed by a round-celled growth. This growth invaded the bones along the 
vascular channels, which were considerably dilated, so that islets of bone appeared embedded in 
the mass of cells. 
The cells were almost entirely of the lymphoid variety, a single large nucleus being alone 
visible in the majority. 
A few oval or spindle cells were seen infrequently, but no myeloplaques or eosinophile 
cells were found. Red blood corpuscles appeared in considerable numbers, but were never 
observed to be nucleated. In addition to the lymphocytal form of cell, larger cells with a 
considerable amount of protoplasm and either a single, double, or reniform nucleus were met 
with (PI. XIII, Figs. 2, 7, and 8). 
The cover-glass preparations showed the same general features, including the absence 
of myeloplaques and eosinophile cells, but owing to the presence of fatty and albuminous material 
they were less satisfactory than the sections. 
The Bone, — The decalcified bone of the sternum and vertebra showed normal features : 
