PREFACE 
' I ^HE experimental work on Trypanosomiasis which the Liverpool 
School of Tropical Medicine has undertaken owes its inception to 
the discovery by Dutton in 1902 of a trypanosome in the blood 
of a European under the care of Dr. Forde. Drs. Dutton and Todd were 
appointed by the School to investigate the disease in Senegambia. The 
expedition returned in the summer of 1903, bringing with them animals 
infected with Trypanosoma gambiensc from natives suffering from the 
disease in Senegambia, and also animals infected with Trypanosoma dimorphon 
(Gambian Horse Disease). As Drs. Dutton and Todd had to leave 
in September, 1903, for the Congo Free State the School decided to carry 
on the research. On my taking charge of the work I was assisted by Dr. 
S. F. Linton, who continued with me until June, 1904. Dr. Anton Breinl 
(J. W. Garrett International Fellow) was then invited to undertake the 
pathologico-histological side of the work. He has been given opportunity 
of studying and comparing material from three cases of sleeping sickness 
and one case of trypanosome fever in man, together with material from a 
large number of animals dying from the various trypanosomic diseases. 
The following gentlemen have aided the research in blood-counting 
observations on the animals: — Dr. R. E. McConnell, Mr. P. A. Radcliffe. 
Special analyses of urine were made by Mr. Edie (Bio-Chemistry Depart- 
ment). In addition to studying T. gambiensc and T. dimorphon other 
pathogenic trypanosomes were procured, so that a comparison could be made 
between the above micro-organisms and T. evansz, T. brucci, T. equinum, 
T. equiperdum. 
Extensive experiments have been made with various drugs to cure the 
disease. Observations have been made upon serum and agglutination 
work. 
The experimental trypanosomiasis research has embraced such a large 
number of problems that my colleague and myself have been unable to 
complete all the lines of work. The experimental work has naturally 
depended largely upon the effects of the disease in animals, and frequently 
the labour of months has had to be repeated by reason of epidemics amongst 
the inoculated animals. 
