6 THOMPSON YATES AND JOHNSTON LABORATORIES REPORT 
May 21 : Condition much worse. Emaciation very marked. Motions passed in bed. Bedsores 
over sacrum, others commencing on ankles, knees, and scapulae. Pulse extremely weak. Extremities 
cold. Gums ulcerated, teeth loose, mouth very foetid. Treatment of no avail. 
May 22 : Taken to Isolation Hospital, Southampton. Condition after two days improved, but death 
took place May 24. Patient was lumbar-punctured six times, on three occasions parasites were present 
in the cerebro-spinal fluid. A rat injected with some of the fluid shortly after death, developed the 
disease in a mild form thirty-five days after inoculation. 
For autopsy and morbid histology, see Part II, Boyo. 
Mpangila. Male. Aet. 17. 
Arrived in Liverpool, December 27, 1904.. Parasites had been found in the blood in November, 
1904., by Dr. Dutton. 
Physical condi/ion : A well-developed boy ; muscular development, fair. Thin, but not emaciated. 
Intelligence, above average. Easily tires ; no tendency to somnolence. Glandular enlargement general. 
Skin soft. No oedema. No eruptions on skin. 
Respiratory system normal. 
Circulatory system : Heart sounds, normal. Pulse, 96-104, soft and regular, at times becoming more 
rapid and irregular, without cause or relation to the temperature, rising to I 10 and falling again to 96. 
This occurred when at rest or during work ; heavy labour did not appear to affect it. 
Spleen : Slightly enlarged ; not tender on palpation. 
Liver normal. 
Genito-urinary system normal. Urine, sp.gr. 1018. No albumen ; no sugar ; chlorides; no bilirubin. 
The following analyses were made by Mr. Edle, Laboratory of Bio-Chemistry : — 
Date 
c.c. 
Urine 
Sp. Gr. 
Reaction 
Litmus 
Grams 
Total 
Nitrogen 
Grams 
Urea 
Grams 
Uric 
Acid 
Grams 
NH., 
Grams 
NaCl 
Grams 
Albumen 
Sugar 
July 9 
1 IOO 
101 5 
Neutral 
lO'I 
20-1 
•51 
I^I 
I-42 
» H 
94.O 
101 5 
Acid 
1C9 
21-6 
•56 
•49 
8-+ 
i'i-5 
I I 60 
1018 
Alkaline 
1 1 -4 
22-8 
•69 
'4 1 
1 3-4 
1-25 
C 
C 
„ 22 
860 
1024 
Acid 
12-3 
24-8 
•69 
56 
ic- 4 
1 -i 
< 
< 
Aug. 1 
I 300 
1019 
Acid 
'4'4 
29-0 
•7 I 
■36 
13-2 
1-29 
I 700 
1022 
Acid 
23-2 
45-8 
i*4 
I -o 
17 
r 9 
Faeces contained ova of Ankylostoma duodenale. 
Ocular, oral, and nasal systems normal. 
Nervous system : Knee jerks normal. All superficial reflexes normal. No tremors. Pupils react to 
accommodation. Electrical reactions normal. 
Sensations : Pain, temperature, taste, and smell normal. 
Glanas : All enlarged, especially cervical and inguinal regions. Easily palpable, freely moveable, 
firm, not painful ; some of cervical were as large as a hazel nut. 
From December 27, 1904, to August 17, 1905, the boy was under observation. He was given 
work in the laboratory and animal houses. No evidences of the progressing of the disease could be 
determined. The boy grew taller and stronger and put on weight, learnt English rapidly, and his 
