1 8 THOMPSON YATES AND JOHNSTON LABORATORIES REPORT 
Experiment 738 
Disease 
Red Corpuscles 
Leucocytes 
TT 
Haemo- 
globin 
Parasites 
4th 
5,24.0,000 
I 2,000 
85 
8 to cover 
5 th 
6,500,000 
I 2,600 
86 
40 
6th 
5,430,000 
I 5,800 
75 
228 
7th 
5,6l0,000 
17,000 
65 
400 
8 th 
5,850,000 
I 8,600 
64 
2400 
9th 
5,540,000 
I 3,600 
79 
2+ 
1 -rh 
4,2 70,000 
60 
5° 
58th 
5,260,000 
1 0,000 
69 
28 
69th 
7,820,000 
I 1,800 
92 
2 
1 66th 
4,3 10,000 
1 4,000 
70 
680 
It appeared to be immune. Its serum did not possess protective properties. Infec- 
tion and progress of the disease occurred in all animals treated with this serum. Its 
agglutinative properties were infinitesimal. Pups born of this bitch were as susceptible 
to the various strains as the control ones. The temperature varies. Usually, in the 
long continued cases, exacerbations of fever with apyrexial periods of eight to ten 
days occur ; sometimes the fever is high and irregular during the whole course of the 
disease. A subnormal temperature is usually recorded before death. One animal 
developed fits eight days before death, and unconsciousness became marked eighteen 
hours before the end. Owing to absence from the laboratory no post-mortem was 
done. Anaemia may or may not be pronounced. Autoagglutination is usually 
pronounced. 
Pups are very susceptible and usually show large numbers of parasites in their 
'olood. Periodicity is sometimes very pronounced, the parasites often diminishing 
from ten to forty to a field to only a few in a coverslip preparation. This may 
occur in the course of a tew hours. 
Cats 
As shown by us, these animals are susceptible to inoculation. The disease runs 
a course of three to ten weeks ; a few have lived for a longer period, six-and-a-quarter 
months. Parasites are generally hard to find, but can be usually found if properly 
looked for. The temperature is irregular, sometimes passing 104/5 apyrexial 
intervals usually occur. It is often subnormal about twenty-four hours before death 
and there may be a steady and regular fall for some days preceding death. 
