TRYPANOSOMES, TRYPANOSOMIASIS, AND SLEEPING SICKNESS 29 
Cats 
Four cats and two kittens have been inoculated. The disease in the adult cat is 
of a chronic nature. The incubation, after intraperitoneal inoculation, is from twelve 
to fourteen days. The duration of the disease in three of the animals was nine to ten 
months, one slightly smaller cat died at the end of forty-six days. The disease pursues 
a chronic course, the parasites are prese it only in small numbers, and often are absent 
for intervals of two to eleven days. The incubation period and the rise of temperature 
occur together (in one cat, 105-2° F.), after that the temperature falls somewhat but is 
exceedingly irregular ; after some time the temperature, though remaining irregular, 
does not rise so high as it did at first. Before death a fall in temperature to subnormal 
is usual. Loss of weight occurs but the weight is very often regained temporarily ; 
a month or so before death the loss of flesh is more marked. Anaemia is present but 
not very marked or progressive. A discharge from the eyes may occur, and in one 
case oedema around the vulva was noted. The coat is roughened. Two cats which 
became pregnant after infection aborted. The foeti were examined but no parasites 
could be found. Small rats inoculated with blood from them never became infected. 
A kitten became infected at the end of seven-and-a-half days and died in 
twenty-three days, the parasites were more constantly present and in greater numbers. 
Anaemia and loss of weight were marked. Discharge from the eyes and nose was 
noted. A seeming partial paralysis' of the posterior limbs was remarked four days 
before death. The temperature rose on the appearance of the parasites and remained 
high but irregular until death. 
Post-mortem. — The spleen in the acute form is enlarged. In the chronic form 
it is only about one-and-a-half times enlarged. The glands are not very big, some 
few may be haemorrhagic, all contain much juice. 
Dogs 
Many dogs and puppies have been used. The average incubation after intra- 
peritoneal inoculation is four to eight days, death has taken place in ten to nineteen 
days. For puppies the incubation is about the same, but the duration appears some- 
what prolonged — nine to twenty-six days. The parasites are continuously present in 
the peripheral blood and increase in numbers, to diminish for a few days. They then 
begin to augment and usually continue to do so up to or just before death. Loss of 
weight and anaemia are prominent features. The temperature, after an initial rise, 
becomes irregular or sometimes continuous ; before death it is usually subnormal. 
Dutton and Todd 2 brought back an adult bitch, Experiment No. 1 1, inoculated 
October 16, 1902. from Horse I, and infected six days later. This animal, August 3 1, 
1903, was well and strong, its blood non-infective. It is still living, no parasites are 
1. While the paralysis is noted no importance is attached to it as young infected animals of all species exhibit such a 
symptom. 
2. Liverpool School of Tropical Medicine, Memoir XI 
