TRYPANOSOMES, TRYPANOSOMIASIS, AND SLEEPING SICKNESS 63 
administered in as high doses as the case can stand. That all aids to building up the 
system should be employed. 
4. That in trypanred we possess an agent of some use in the treatment of 
trypanosomiasis. That certain trypanosomic diseases appear to be more amenable 
to its action than others. That in the substance at present available there is need for 
improvement in order to abolish its toxic effects. 
5. That a combination of arsenic and of an improved form of trypanred would 
seem indicated in the further investigation of the cure of trypanosomiasis. 
6. That further efforts ought to be made to produce less toxic forms of arsenic 
suitable for injection. 
7. That the action of both arsenic and trypanred causes a hyperleucocytosis 
and that this condition has an effect upon the parasites. In confirmation of this is to 
be recorded : — 
The hyperleucocytosis coincides with the time when the parasites suddenly 
disappear from the peripheral circulation. 
(b) There is a smaller number of parasites present in necrotic, bacterially- 
infected areas than in the general circulation. 
(c) The effect of certain bacteria on animals infected with trypanosomes. 
