TRYPANOSOMES, TRYPANOSOMIASIS, AND SLEEPING SICKNESS 69 
and contained a tew lymphocytes. Many of the liver cells had no nucleus, the 
protoplasm was vacuoli , and in various stages of fatty degeneration. A tew of the 
cells contained small clumps of yellowish pigment occupying more than hall of the 
cell. The blood vessels which were very much congested, contained a limited number 
of white blood corpuscles. 
The kidneys presented the picture of parenchymatous degeneration. The 
protoplasm of the epithelial cells showed granular degeneration. The blood vessels, 
especially in the cortical region, contained very many white blood cells, and here and 
there in close proximity to the vessel wall were numerous red blood corpuscles. In places 
only scanty remains of normal kidney tissue were visible, the field being occupied by 
well stained connective tissue, its meshes entirely filled with red blood corpuscles. 
The glomeruli showed the same congestion, distended capillaries sometimes forming- 
more than two-thirds of the whole glomerulus. 
The spleen in section showed a thickening of its capsule. The malpighian bodies 
were few in number and not prominent, and from them irregularly defined processes 
ran out into the surrounding tissue. There were two zones to be made out in a 
malpighan body, viz., an external zone consisting only of lymphocytes, and a central 
one consisting of large cells containing a vesicular nucleus. Amongst the latter were large 
non-nucleated cells (forty to fifty m in diameter), the protoplasm of which stained a 
dull red with eosine, and in addition a few leucocytes with eosinophile granules. The 
trabeculae were hyperplastic, and the vessels showed endothelial proliferation. The 
congestion of the spleen was most striking, especially in the periphery. Interspersed 
in the tissue were red blood corpuscles, sometimes clumped together in dense irregular 
heaps, in which a few lymphocytes were also included. The red cells showed indistinct 
contours, and by their staining reaction were evidently degenerated. Here and there 
were small irregular necrotic areas, in which only a few connective tissue cells were 
present. The cellular elements of the organ included very numerous large hyaline 
cells, containing inclusions of red and white cells, a very few nucleated red cells in 
the larger vessels, and, in the tissue of the pulp, giant cells with numerous irregularly 
placed and irregularly shaped nuclei and a large protoplasmic body. Throughout the 
spleen are found mono- and polynuclear leucocytes with eosinophile granulation. 
Iron-containing pigment is occasionally seen, both intracellular and free. In the 
vessels and in the tissue itself occasional filaria embryos were met with. 
Lymphatic Glands. — The most marked changes were found in the lymphatic 
glands. The vessels were found to be highly congested in accordance with the naked 
eye appearance. Side by side with normal glands, in nearly all groups, there were others 
which contained very numerous red corpuscles, lying free in sinus-like spaces partially 
filled with large phagocytic cells. In nearly all the lymphatic groups were also 
transitional forms between normal glands and those showing the above described 
changes. The changes bore no proportion to the size. In the same lymphatic gland 
