70 THOMPSON YATES AND JOHNSTON LABORATORIES REPORT 
often one part would be quite normal, while another part showed typical sinus 
formation. 
These enlarged glands in the first stage of their formation showed a thickened 
capsule, with bands of fairly thick connective tissue running in from it towards the 
centre and containing enlarged vessels showing distinct proliferation of their endo- 
thelium. In some places the lymphoid tissue does not reach right up to the capsule, 
but a lightly stained fine connective tissue meshwork intervenes, which contains, 
besides a few lymphocytes, a number of red corpuscles, large phagocytes, and iron- 
containing pigment granules. The nucleus of the phagocytes is peripherally placed, 
and their inclusions consist of the following : — numerous darkly-stained nuclei, the 
size of lymphocytes, and red blood cells which either stain yellow with Van Gieson's 
method or appear merely as unstained vacuolar areas in varying number often filling 
the whole cell. The intervening spaces in the sinus are filled with coagulated fluid. 
Sinuses with the same contents as the peripheral one are found in very small numbers 
in the interior of the gland, recognizable at the side of the connective tissue strands 
by their light staining. The follicles are not so distinct as normally ; they are larger 
and not sharply defined from the surrounding lymphoid tissue. 
The majority of the smaller glands presented a similar microscopic appearance ; 
frequently there were a good number of red corpuscles between the lymph cells, and 
the sinus system was more or less pronounced. Sometimes there occurred only a 
short peripheral sinus, with one or two central off-shoots ; in other places, the whole 
gland was interlaced by them. In some the follicles were normal, in others lightly 
stained, and contained, in addition to larger vacuolated cells and lymphocytes, a fair 
number of small cells two-thirds the diameter of a red blood corpuscle, which had 
an eccentric, deeply-stained, small nucleus and protoplasm staining faint pink with 
eosin. Besides, there were very many small nuclei both free and contained in other 
cells, staining darkly with haematoxylin. The blood vessels were much dilated, and 
contained, besides lymphocytes, a good number, as a rule, of large mononuclear and 
polymorphonuclear leucocytes and a few eosinophile cells. 
Some of the larger lymph glands showed the change in a more advanced stage 
(see Fig. 6). In these, by a marked hyperplasia of the connective tissue, the lobules of 
lymphoid tissue became contained in a framework of connective tissue, producing 
thereby an alveolar structure. In the centre of the gland, an accumulation of 
connective tissue was extended by radiating septa to the capsule ; this was thin, and 
had large dilated vessels surrounded by numerous lymphocytes running in it. There 
were no fat cells in the connective tissue of the glands, showing that these were true 
lymphatic glands, and not new formations in the adipose tissue. The sinus formation 
was as described in the first stage. Around the congested vessels were nearly always 
deposits of red corpuscles with a little blood pigment. Follicles were not to be seen. 
Fig. 7 shows this transformation in one of the mesenteric glands. A. sinus is 
