TRYP 4.NOSOMES, TRYPANOSOMIASIS, AND SLEEPING SICKNESS 77 
fibres was frequently indistinct, and showed accumulations of brown pigment around 
their nuclei. 
The l-ioig presented a remarkable congestion. The vessels ot the alveolar septa 
were cork-screw shaped, projected into the alveoli and contained plenty ot" large 
mononuclear leucocytes. In some places were signs of commencing pneumonia. The 
alveoli were filled with a varying amount of exudation containing eosinophils, and a 
large number of red blood corpuscles. There was striking hyperplasia of the lymphoid 
tissue around the bronchi. In the inflamed parts of the lung were a varying number 
of diplococci (stained by Gram's method) and a few bacilli. 
The Liver showed a little hyperplasia of the connective tissue. The cell rows 
were attenuated ; of the nuclei some were only faintly stained, others unstained ; the 
protoplasm being often merely an accumulation of various-sized fat droplets. No 
pigment was visible. Here and there ware accumulations of red corpuscles between 
the liver cells. 
The Kidney showed hyperaemia to such an extent that in some small places there 
was no epithelium to be seen, but only a delicate connective tissue with its meshes 
filled with red blood corpuscles. The glomeruli were often half-filled by dilated 
capillaries. Around the vessels were haemorrhages. Here and there parenchymatous 
degeneration was pronounced, the tissue being transformed into a homogeneous mass, 
with occasional tubules and a few epithelial cells left, and the whole traversed by 
numerous congested vessels containing many leucocytes. 
The Spleen showed hypertrophy and hyperplasia of its follicles. The malpighian 
bodies were sharply defined and showed a light centre of large, irregularly-shaped 
cells with vesicular nuclei, other cells with much protoplasm and numerous (six to 
eight) irregularly situated, segmented nuclei, and a few mono- and polynuclear 
eosinophiles — -all these cells being held in a fine meshwork of connective tissue. 
Around this centre is a corona of very densely-packed lymphocytes, while the 
external part is made up of the same interspersed with red blood corpuscles and 
polymorphonuclears. The congestion is very noteworthy, especially in the peripheral 
parts, where often nothing is visible beyond very thin sinus walls, surrounded by 
innumerable red cells. The sinuses contain many leucocytes, with a few phagocytes 
among them. The difference in staining reaction of the red ceils is striking. In 
the van Gieson stained specimen, some of the corpuscles took the picric acid very 
intensely, others being only faintly or not at all stained. Sometimes they were 
clumped together and showed small iron-containing pigment granules ; these being 
found all over . the spleen, and both free and intracellular, as tor example, in the 
endothelial cells of the sinuses. The arteries show proliferation of their endothelium, 
and contain a fair number of leucocytes and a few megaloblasts. The spleen tissue 
contained phagocytes (with included red blood corpuscles and nuclei of lvmphocytes) 
plasma cells, many eosinophiles, and giant cells ot mononuclear type. 
