PANi REATIC JUICE. 
367 
A temporary fistula should be made two or three hours after a meal, 
and the fluid collected during the uexl 1 wo or three hours. The greater 
number of such fistulas have been made on dogs. The fluid obtained is 
clear like water, bul of a slimy, syrupy consistency; it becomes still 
more viscid as it cools, and undergoes at,0°C. a true coagulation, separat- 
ing into a gelatinous and a fluid portion. Its specific gravity is about 
1 '030. It contains in suspension white corpuscles, which exhibit sluggish 
amoeboid movements. It is alkaline in reaction, the alkalinity being 
equal to 0'2— 0*4 per cent, of NaHO, but the first few drops secreted may 
be acid. The alkalinity is commonly said to be due to carbonates 
and phosphates of sodium. The fluid is rich in proteid, froths on 
shaking, and on heating to 75 C. coagulates to a solid white mass. 
If kept warm for some time, its proteids become peptonised by the 
trypsin present with them. On dropping into water a precipitate is 
formed, which is soluble in dilute saline or acids. Alcohol gives 
an abundant flocculent precipitate, mostly soluble in water, and con- 
sisting of the proteid and enzymes. Leucine is present in traces, 
but not tyrosine. Similar secretions have been obtained from many 
other animals: the pancreatic juice of herbivora (rabbit, ox, and sheep) 
contains much less proteid than that of carnivora, but is in other 
respects similar. 
The permanent secretion sets in at a variable period, from a 
few hours to some days after the operation. It is very similar 
to the temporary secretion, except in containing much less organic 
matter, and in having in consequence a much lower specific gravity, 
1-010-1011. 
Quantitative chemical composition. — The following table gives the 
results of analyses of both temporary and permanent secretions of dog's 
pancreatic juice by C. Schmidt : 1 — 
1. Analyses of Temporary Secretion", obtained 
directly after the operation. 
2. Analyses of Secretion, obtained 
from Permanent Fistil.e. 
a. 
b. 
a. 
b. 
c. 
Water .... 
Total solids 
Organic matter . 
Ash . 
900-8 
99-2 
90-4 
8-8 
884-4 
115-6 
976-8 
23-2 
16-4 
6-8 
979-9 
20-1 
12-4 
7-5 
984-6 
15'4 
9-2 
6-1 
3. Composition of the Ash (in parts per 1000 parts of Pancreatic Juice). 
(a) From Teniporary 
Secretion. 
(b) From Permanent 
Secretion. 
Soda (Na 2 0) 
Sodium chloride ...... 
Potassium chloride ...... 
Earthy phosphates with traces of iron 
Trisodic phosphate (Na 3 P0 4 ) .... 
Lime (CaO) and Magnesia (MgO) 
0-58 
7-35 
0-02 
0-53 
0-32 
3-31 
2-50 
0-93 
0-08 
o-oi 
o-oi 
1 Quoted from Maly, Hermann's "Handbuch," Bd. v. (2), S. 189. 
