5 68 
MECHANISM OF BILE SECRETION. 
Among these substances are the salts of the bile acids, and all in- 
vestigators find that the administration of these causes an enormous 
increase in bile secretion. But while such pure hemolytics as toluy- 
lenediamin and arseniuretted h} r drogen cause only a transitory increase 
in the secretion, and produce a very concentrated bile, the bile salts not 
only markedly increase the solids, but also the water secreted. The 
following record of one of Eosenberg's x experiments shows this effect : — 
Time in Hours. 
Amount of Bile. 
Per Cent, of 
Water. 
Per Cent, of 
Solids. 
At 8.30-9.30 A.M. . 
47673 
94-4 
5-6 
10 grs. bile with 1'16 grs. solid 
s given at 9.30 
,, 9.30-10.30 ,, 
6-9095 
95-3 
4-7 
„ 10.30-11.30 ,, . 
12-9783 
93-9 
6-1 
„ 11.30 A.M. -12.30 p.m. . 
3-6582 
90-S 
9-2 
,, 12.30-1.30 p.m. . 
2-3897 
88-9 
11-1 
Again, Stadelman's work shows that, while the ordinary hemolytics 
do not increase the secretion of bile salts, the administration of the 
bile salts leads to a marked increase in their percentage amount in the 
bile. Paschkis' experiments 2 indicate that, while glycine and taurine 
have little action as cholagogues, cholalic acid is exceedingly active. It 
would thus seem that these substances act not only in virtue of their 
hemolytic action, but by reason of a special stimulating influence upon 
the liver cells. 
Salicylate of soda, which also has a hemolytic action, greatly 
increases the flow of bile. But while the bile salts cause an increase 
in the solids, this substance produces a very marked dilution of the 
bile (Eutherf ord, 3 Lewaschew, 4 and Eosenberg 5 ). 
One of Eosenberg's experiments is here given to show this effect. 
Time in Hours. 
Bile Secreted. 
Per Cent, of 
Water. 
Per Cent, of 
Solids. 
At S-9 a.m. . 
1-2944 
80-6 
19-3 
., 9 „ 
2-0 grs. 
salicylate of soc 
a given 
,, 9-10 ,, 
6-2885 
90-7 
9-3 
,, 10-11 „ 
4-2914 
92-3 
7 - 7 
,, 11 a.m. -12 noon 
4-521S 
92-1 
7-9 
,, 12 noon-1 p.m. . 
4-6437 
91-8 
8-2 
1 Loc. cit. " Loc. cit. 
3 "Action of Drugs on the Secretion of Bile," Edinburgh, 1880, p. 118. 
4 Ztschr.f. klin. Med., Berlin, 1SS4, Bd. viii. S. 67. 
5 Arch. f. d. ges. Physiol., Bonn, 1890, Bd. xlvi. S. 355. 
