INEZ UENCE OF BRAIN ON HE A T REG ULA TION 863 
stimulation as well as by puncture of that portion of the nervous 
system, and are probably due to traumatic stimulation. It is to be 
noted that irregular muscular movements were observed in many of the 
cases. 
Schreiber, 1 from the results of experiments performed upon rabbits, 
came to the conclusion that a rise of temperature followed injury 
to all parts of the pons, to the pedunculi cerebri, cerebellum, and 
cerebrum, when the animal was protected by a covering of wool or 
flannel against excessive loss of heat ; injury between the medulla 
oblongata and the pons always caused a rise in temperature. In most 
cases, however, the rise in temperature was very small, and the experi- 
ments were often complicated by spasms of the muscles. 
Observations upon the production of heat, as determined by a 
calorimeter, and also upon the animal's temperature after lesions of 
various parts of the central nervous system, were made by Wood. 2 
Section of the spinal cord above the origin of the splanchnic nerves 
produced an increase in the loss but a decrease in the production of 
heat ; on the other hand, section between the medulla oblongata and the 
pons caused an increase in both the production and loss of heat, and for 
this reason Wood supported the view of Tscheschichin, that a moderator 
centre exists in or above the pons. 
Eulenberg and Landois 3 found that in dogs destruction of a portion 
of the cortex of the brain in the neighbourhood of the sulcus cruciatus 
caused a rise of temperature, which was most marked on the side of 
the body opposite to the lesion : they looked upon this effect as due to 
vasomotor disturbance. These results were confirmed by Hitzig 4 and 
Wood, but on rabbits Kiissner 5 and H. Eosenthal 6 obtained negative 
results. 
Injury to the front of the brain was found by Kichet 7 to produce a 
rise of temperature, and Ott 8 obtained a similar result by injury to the 
corpus striatum ; this observation was confirmed by Girard, 9 Bagmsky 
and Lehmann. 10 In 1885, Aronsohn and Sachs 11 published the results 
of an important series of experiments upon rabbits ; they found that 
puncture with a probe, the greatest thickness of which was 3 mm., 
had no effect upon the temperature of the body when the operation was 
performed upon the front part of the cerebral hemispheres, but a 
puncture passing through the median side of the corpus striatum near 
the nodus cursorius of Nothnagel caused, within a few hours, a rise of 
temperature which persisted for two or three days. The rise varied 
from l c- 7 to 2° -4, and could also be produced by electrical stimulation of 
the corpus striatum. Control experiments showed that the injury to 
1 Arch. f. d. ges. Physiol., Bonn, 1874, Bd. viii. S. 576. 
2 "Fever, a Study in Morbid and Normal Physiology," Smithson. Contrib. Knoicl., 
Washington, 1880. 
3 Centralbl. f. d.med. Wissensch., Berlin, 1876, No. 15; V'rrchovis Archiv, 1876, 
Bd. lxviii. S. 245. 
* Centralbl. f. d. tried. Wissensch., Berlin, 1876, No. IS. 
5 Ibid., 1877, No. 45. 
6 "Einfluss des Grosshirns auf des Korperwarme," Diss., Berlin, 1877. 
7 Compt. rend. Soc. de biol., Paris, 29th March 1884, p. 189 ; Compt. rend. Acad. d. sc, 
Paris, 31st March 1884 ; Arch, de physiol. norm, etpath., Paris, tome vi. 
8 Journ. Nero, and Merit. Bis., N.Y., 1884, Nos. 7 and 8 ; 1887, p. 152 ; 1888, p. 551 ; 
Therap. Gaz., Detroit, 1887 ; Brain, London, 1889. 
9 Arch, de physiol. norm, et path., Paris, 1886, tome viii. 
10 Virchow's Archiv, 1886, Bd. cvi. S. 258. 
11 Arch. f. d. ges. Physiol. Bonn, 1885, Bd. xxxvii. S. 232. 
