Development of Piroplasma Parvum in Variotis Organs of Cattle. 65 
self had surmised. Accordingly the view of Martin Mayer, that the so- 
called Koch's granules are not specific for East Coast Fever, falls to the 
ground. 
The hlue bodies represent, indeed, a certain stage in the cycle of 
P. parvum tuhich corresponds to the shizogony in the cycle of the malarial 
and other parasites. 
These bodies appear both intracellularly and extracellularly, more par- 
ticularly in the lymphocytes. Quite exceptionally poly nuclear leucocytes 
are found to be infected. The development takes place more or less in 
the following manner. In the blue body (Agamont) the nucleus is first 
formed ; this grows and becomes richer in chromatin and plasma ; subse- 
quently it divides successively into a great number of smaller nuclei 
similarly to what occurs in the cycle of hsemoproteus which takes place in 
the organs of the pigeon and padda. The cells thus formed break up into 
as many subdivisions as there are nuclei (Figs. 1-6). One encounters but 
rarely a second one, to which I will refer hereafter. The explanation of 
this fact may be that this shizogonous stage, which I call, with Hartmann, 
Agamogony, repeats itself. Accordingly agametes, resulting from the 
agamogonous stage, would grow into agamonts. I have, however, not 
been able to completely follow up the further development of these later 
forms. 
The second mode of multiplication ends with the segmentation into a 
great number of small parasites, undoubtedly resulting from the agamo- 
5 
