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Transactions of the Boyal Society of South Africa. 
gonous multiplication (Figs. 7-13). The young parasites enter into the 
red corpuscles, and represent now the forms known as P. parvum. Thus 
we have in the organs, particularly in the lymphatic glands and the spleen, 
two different phases, which morphologically are not difficult to distinguish 
from each other. The nuclei of the one phase (agamogonous) when young 
show a loose structure, and are irregularly shaped. The nuclei of the 
second phase, that is, of the second generation or gamogonous, take the 
nuclear stains more deeply ; they undergo reductions, and accordingly 
appear smaller. Before the segmentation of the nuclei has taken place 
they are oval-shaped. One is struck by the fact that the extracellular 
segmenting forms of the gamogonous generation produce parasites in far 
smaller numbers (Figs. 14-15) than those found in the cells themselves 
16 
*'*•••**« 
13 
14 
(Figs. 12-13). I have not been able to give an explanation of this obser- 
vation. In the blood no multiplication has as yet been seen, but my 
studies on these parasites are not yet concluded. Plasma granules were 
found in the blood, but this fact by no means necessitates a change of the 
above technology. It may also be possible that two agamogonous stages 
have to be distinguished, and the parasites which develop in the red cor- 
puscles would have to be considered as the gamogenous generation. I am, 
however, of the opinion that the two stages in the cycle which I have 
called provisionally agamogony and gamogony, and which finally lead to 
the formation of the forms seen in the blood, succeed each other within 
the cell. Accordingly it is clear that the number of parasites increase 
as the disease develops. The forms which result from the segmentation 
of the last generation differ morphologically in no way from the parasites 
