224 
TODD AND WOLBACH. 
evidences of cloudy swelling and there are occasional groups of lymphoid 
and plasma cells between the tubules. The connective tissue of the 
apices of the pyramids is edematous and contains occasional mitotic 
figures. The blood vessels are normal. There are a few hyaline drops 
and vacuoles in the epithelial cells of the pelvis. Adrenal: Normal. 
Parotid gland : Normal. Muscle : A few of the fibers of muscle taken 
from the diaphragm and leg contain cysts of Sarcosporidium. The fibers 
are very slightly enlarged by the cysts. Intestines: Sections from large 
and small gut are negative except for lesions due to the attachment of 
Sclerostomum equinum in the large gut. Bladder: Negative, except 
for some edema of tissues beneath the peritoneal coat. Lymph glands : 
The superficial lymph glands are normal. Those from the peritoneal and 
thoracic cavities all showed marked congestion and dilated lymph sinuses. 
The surrounding areolar tissues usually contain dilated lymph vessels. 
Another constant finding is the presence of blood pigment in phagocytic 
cells in the sinuses and reticular tissue. The sinuses contain many 
phagocytic, mononuclear cells with inclusions of red blood corpuscles, 
pigment and lymphoid cells. There is no necrosis. Occasionally lymph 
sinuses contain fibrin and large mononuclear cells and a few red blood 
corpuscles. Clusters of large, mononuclear cells, containing minute 
granules and vacuoles, are common in the reticulum of many glands. In 
one gland there are several giant cells of the bone-marrow type. Bone 
marrow : That from the femur is fatty and contains no blood-forming 
elements; that from the rib is active and normal in appearance. Brain 
cortex: Normal. Spinal cord: Normal. Peripheral nerves: Normal. 
Case II. (Grey Gelding). — Age, 17 years; weight, 1,205 pounds; 
received January 19, 1910. This animal also came from Oakville, Mani- 
toba. It was first noticed to be ill in July, 1909 ; since then it has been 
only fit for work at intervals. On the 7th of January its pulse was 60^ 
and its temperature 99° F. There was slight edema of the abdomen and 
marked anemia of the mucous membranes. The heart sounds were 
increased and polyuria was present. The horse was said to be becoming 
steadily thinner in spite of a good appetite. 
Present condition : The horse seems to be practically healthy. The 
gait is slow, but not uncertain ; and the horse is thin, but not emaciated. 
The only edema to be detected is a slight thickening of the sheath ; the 
mucous membranes are not very pale and there are no petechias. The 
blood count shows that there is a slight anemia; there are 6,500,000 red 
cells and about 60 per cent of hemoglobin. 
Course of the disease : On April 23d. the horse was much improved ; 
it weighed 1,360 pounds, its pulse rate was 44 and its temperature, which 
was usually about 100° F., had not been above 101° since its arrival. 
There was no anemia. A blood count gave : red cells, 8,500,000 ; white 
cells, 16,000 ; hemoglobin, 70 per cent. At the middle of May and at the 
commencement of June there were slight rises in temperature, lasting for 
a day, or, at most, two, to 102° F. The rise at the end of June was due 
