CELLULAR CONTENT 
43 
and specimens in which such intermingling occurred throughout an entire 
node, or an entire section even, were still less frequent. Although a good 
deal of intermingling occurred in some specimens, both lymphocytes and 
erythrocytes were segregated more or less distinctly as a rule ; and even 
in nodes which contained but remnants of lymphatic tissue the lympho- 
cytes were formed into small circumscribed areas or groups near the 
radicles of the venous system. The constancy in staining characters :>f 
the lymphocytes was in striking contrast to that of the erythrocytes and 
acidophiles. However, in nodes which practically represented a sac of 
blood in which the small remaining masses of lymphocytes were sur- 
rounded more or less completely by remnants of the framework of the 
node, both protoplasm and nuclei of the lymphocytes occasionally assumed 
very irregular shapes. In other cases the nuclei stained poorly, and the 
nuclear network was indistinct; while in still others they were pyknotic 
or had apparently fragmented. 
Variations in the size of the lymphocytes within the same or in differ- 
ent nodes were considerable ; but often these were apparent and not real, 
for these fluctuations were chiefly due to variations in the size of the nu- 
clei, rather than to differences in the quantity of cytoplasm present. Since 
however, the cell outlines were very frequently indistinct, while those of 
the nuclei were well defined, these observations were not wholly satisfac- 
tory. The protoplasm was often not eccentric; and where, as in case 
of the center of the follicles, the cells were closely packed, they were much 
larger, had vesicular nuclei, and frequently a more or less polygonal 
outline. The size and number of the chromatin granules varied greatly, 
the smaller ones being more common near the periphery of the nucleus, 
while the larger ones, on the contrary, lay nearer the center. The chro- 
matin network too was often quite distinct, but well-defined nucleoli were 
infrequent. Moreover, the nuclei of cells which lay near the periphery 
of the follicle, were usually more regular in shape, and were often entirely 
filled with granules ; while those nearer the center, besides usually being 
vesicular, larger, and more irregular in shape, contained but few granules. 
Unmistakable mitotic figures could not always be found in the follicles, 
and still less frequently in other parts of the nodes. Since, however, a 
comparatively small number of specimens were prepared for this partic- 
ular purpose, these statements may not be thoroughly representative. 
The apparently excellent state of preservation of the blood, in both 
the parenchyma and subcapsular blood spaces, in the great majority of 
nodes, is in marked contrast to the degenerated condition frequently 
observed in the lacunae of Weidenreich or true venous sinuses. Nucleated 
