198 
A Piebald Family 
Next in the fourth generation were twins, IV. 6' and 7, both piebalds. They 
were evidently not uniovular, because one had dark hair, and one light, and the 
white blazes were dissimilar in extent, but it is uncertain which had the larger. 
Both died at an early age. 
The next, IV. 8, a girl, was normal with dark hair and eyes and remained 
unmarried. Next came a woman, IV. 10, who was a piebald with a large frontal 
blaze, white eyebrows and eyelashes, and white skin on the front of the neck and 
forearms. The right eye was blue, and the left hroiun (see Plate XIII (B)). Her 
child, aged 13, is quite normal with light hair and dark eyes. 
The next child, IV. 12, Mrs W , has a large frontal blaze and dark brown 
irides. There is a large irregular patch of white skin extending from just below 
the chin to the heads of the clavicles, and round it the skin appears to be more 
deeply pigmented than the rest of the skin of the neck. There are a few small 
islands of pigmented skin near the edge of the unpigmented area. The skin of 
the anterior aspect of the forearms is unpigmented from the elbows to the wrists, 
and here also, there are some small islands of pigmented skin in marked contrast 
to the unpigmented area, in which they lie (see Plate XIV). 
The first two children of this individual were daughters, V. 8 and V. 9, both 
piebald, the third a normal son, V. 10, and then three more piebald daughters, 
V. 11—13. The first of the daughters, Mrs G , V. 8 (see Plate XIV), is very 
fair with a very large frontal blaze covering the whole of the top of the head, 
and her eyebrows and eyelashes are white. Her normal hair has pale creamy 
diffused pigment and, according to the individual hair, some to a decided number 
of granules*. The hair of the blaze has no diffused pigment and no granules. 
The irides are light brown, but the outer segments on both sides are paler and 
greenish in colour. The skin of the forehead and base of the nose is very pale in 
colour. She has a large white patch on the skin of the front of the neck, beginning 
just below the chin and widening out so as to embrace that over the inner ends 
of both clavicles. As in her mother there appears to be some concentration of 
pigment round this white area, and there are small isolated areas of pigmented skin 
near its edge. She has unpigmented skin on the anterior aspect of both forearms. 
Of her two children the first, VI. 1, a boy aged 3, is normal, the second, VI. 2, 
a boy aged 1^, is a piebald (see Plate XIV). This child, VI. 2, was nine months 
old when first seen. He had a very large frontal blaze, resembling that of his 
mother and covering all the top of the head, the eyebrows and eyelashes were 
white with the exception of some of the outer hairs. Hair, pale cream in colour, 
said to be from the light area, has pale creamy diffused pigment and some granules 
{j3), the granules being very small. It was obvious, even at this age, that hetero- 
chromia iridis was present. The right iris was pale except for a sector of dark 
grey occupying the upper and outer quadrant, the left iris was entirely dark grey. 
No difference in colour of the skin of the neck or forearm could be made out. 
* /3 to 7 on the Galtou Laboratory scale of granular pigmentation. 
