E. A. Cockayne 
199 
When the baby was seen after the summer of 1913, the grey portions of the irides 
were becoming brown, the pale portion was still liglit blue. The face and arms were 
sunburnt, and it was noticed that the forehead was paler than the rest of the face. 
There was a pale area on the front of the neck, and the whole anterior surfaces of 
the forearms were white, the edges being very irregular in contour. There was 
also a white streak running obliquely right across the posterior or extensor aspect 
of the left forearm, and this offered a marked contrast with the rest of the surface, 
which was very brown. When the sunburn had died away the difference between 
the pigmented and unpigmented skin could no longer be made out. 
IV. 12's second daughter, V. 9, aged 23, has only a small cream coloured 
frontal blaze, and the rest of her hair is light brown (see Plates XV and XVI). 
The eyebrows are composed of an even mixture of brown and white hairs, and 
the eyelashes are similar, with brown and white hairs alternating. The irides are 
grey and uniformly pigmented. There is a large irregular area of white skin at 
the base of the neck. 
The whole of the anterior aspect of the right forearm is unpigmented, and 
there are similar small areas scattered over the posterior aspect (see Plate XVII). 
The left forearm is white only on the anterior aspect. 
The next girl, V. 11, is aged 9. She has a very small frontal blaze, but the 
skin of the forehead is pale (see Plate XV). The eyebrows show a division into 
two parts, on the inner halves grow white hairs only, and on the outer brown hairs. 
The eyelashes on the contrary consist of alternate brown and white hairs. The 
irides are grey and uniformly coloured (see Plate XVIII). There is only a small 
white area in the middle of the front of the neck, but there are well differentiated 
white areas on the anterior aspects of both forearms (see Plate XIII (A)), and on 
the inner aspects of both upper arms. Her hair was examined and the first sample 
showed very pale diffused pigment and some granules (^). Two more samples 
were then examined, one from the blaze and one from the neighbouring part of 
the scalp. The first showed no diffused pigment and no granules, the second 
showed the majority of hairs with yellow-brown diffused pigment and a decided 
number to plenty of small granules (7 — 8), but a few had no diffused pigment 
and no granules. 
The next piebald child, V. 12, died young. She had a frontal blaze and blue 
irides. Some of her hair showed very pale diffused pigment, and some granules {/3). 
The next child, V. 13, also died young. She was a piebald nearer to the 
classical type than any of the others. She had a large frontal blaze, white skin 
on the forehead, and large areas of white skin on the front of the neck and 
chest, and in addition a very extensive area on the abdomen. 
Of the fourth generation the next child, IV. 13, was a male with dark hair and 
eyes, who had 5 normal children; the next, IV. 15, had fair hair and died young. 
Twins, IV. 16 and 17, came next and died in infancy*. They were heterogeneous, 
* The tendency to twin in this family is worth noting. 
26—2 
