Brown Institution on Pleura-Pneumonia. IGl 
collection of liquid, and particularly by using it only in an 
absolutely fresh state, to avoid the inflammatory results which 
have been above described. Five animals were inoculated with 
perfectly fresh material from a cow killed the same morning 
(see Appendix II.). A few drops of the clear exudation-liquid 
from the lungs were injected under the skin either of the shoulder 
or of the side of the neck. For five days the animals remained 
well ; on the sixth day a swelling appeared at the puncture, 
which gradually increased. In three of the cases it began to 
subside a week after it had commenced, and eventually dis- 
appeared ; but in the other two it went on increasing until it 
had involved the integument of the neck, chest, and belly, at 
length causing death by general infection, in the one case on 
the twelfth, in the other on the fifteenth day of the illness. It 
is to be noticed that the animals exhibited no loss of appetite, 
nor any other sign of general disturbance, until the third or fourth 
day after the swelling appeared, nor did the temperature begin 
to rise in any instance until that time (see Appendix II.). In 
the two fatal cases the highest temperature, four and a half 
degrees above the natural standard (106 "4 Fahr.), was reached 
three days before death. 
The mode of progress of the illness indicated very distinctly 
that, although we had not communicated pleuro-pneumonia by 
our inoculations, we had introduced an infection of another 
kind. If the liquid injected had been a mere irritant it would, 
if its action had been intense enough, have produced a limited 
abscess, not a rapidly-spreading and diffuse infiltration. That 
this was so was confirmed by the appearances observed after 
death. The internal organs, and in particular the lungs, were 
found to be perfectly healthy ; but the serous membranes exhi- 
bited the appearances ordinarily observed in animals that have 
died of acute general infection, that is, from what is popularly 
called blood-poisoning. 
In the cases I have related, the effects of inoculation were, as 
has been seen, severe in every instance ; for even in the three 
animals that recovered, the disturbance of health, as indicated 
by the high temperature and general state of the animal, was 
considerable. When the tail is selected as the seat of inocula- 
tion the case is much more manageable. Here, as before, it is 
not until the fourth or fifth day that the seat of puncture becomes 
painful and swollen. The swelling continues for about a week, 
by which time a slough of dead tissue has usually formed, which 
eventually separates. About the time that the slough comes 
away secondary swelling usually begins, and gradually extends 
to a greater or less distance towards the root of the tail, until, 
in unfavourable cases, the neighbouring integument is involved, 
VOL. XV.— S. S. M 
