Brawn Institution on Pleuro-Pneumonia. 163 
followed br no morbid effects, either local or constitutional. In 
one instance, however, that of an old cow, unfavourable symp- 
toms presented themselves on the sixteenth day after the intusion. 
On that dav the bodily temperature, which at the time had been 
natural and had until then continued so, rose to 103" 2' Fahr., 
and on the day following to 105 • 6^ At this point it remained 
until the twenty-second day, after which it declined till death, 
which occurred two davs later. The rise of temperature was 
attended with other signs of fever, and with difhcult breathing, 
which continued to the last. The post-mortem examination re- 
vealed that the cause of death was an acute double pleurisy ; but 
in addition to this there were appearances which showed that the 
animal, which was thirteen years old, had suffered from chronic 
lung disease of very old standing. This, although not the 
immediate, was the predisposing cause of death. The imme- 
diate cause was, I have no doubt, the infusion, which, acting on 
the pre-existing disease, occasioned consequences to which a 
healthy animal would not have been exposed. It is perhaps 
desirable to add that the affection of the pleura from which 
this animal suffered, although properly called a pleurisy, was of 
an entirely different kind from the pleurisv which forms part 
of pleuro-pneimionia. The sub-pleural tissue, which in the 
contagious disease is the principal seat of alteration, was in this 
animal entirely unaffected ; nor were anv of those characteristic 
chancres in the lunj tissue observed which have been so well 
described by Mr. Yeo in this Journal. We are therefore justified 
in concluding that, whatever may have been its antecedents, it 
was free from pleuro-pneumonia during the time that it was 
under observation. 
The remaining seven animals were, as has been already 
reported to the Society, exposed to the infection of pleuro- 
pneumonia in the most effectual manner that could be devisetl. 
They were removed from the Brown Institution, and placed in 
sheds which were at the time occupied bv diseased animals, and 
in stalls in which such animals had stood. They remained 
under these conditions for three months, and in some instances 
for four, after which they were kept under observation for periods 
which in the majority of the cases extended to six months. 
None of them showed any sigrns of infection. In those that 
were slaughtered (see Appendix V.) the lungs and other internal 
organs were found to be perfectlv healthy. 
■The other six animals were inoculated earlv in the present 
year ; but in consequence, first of our being unable to meet with 
cases ol pleuro-pneumonia in situations convenient for our 
purpose, and subsequently of the obstacles imposed by legis- 
lation, all attempts to test the immunitv of these animals in 
M 2 
