liepai't on Experiments in reference to Plcuro- Pneumonia. 453 
charge from the nostril. It was then transferred to the nostril 
of the experimental animal and retained there for upwards of half 
an hour. As in the former case, the animal was closely watched 
for several weeks — during the time, in fact, which pleuro-pneu- 
monia is often known to lie dormant in a herd in which the 
disease is taking its natural course ; but again no ill effects 
followed. Besides these two experiments with one animal, some 
mucus obtained from the respiratory organs of diseased cattle was 
rubbed on several occasions upon the mucous membrane of the 
nostrils of other of the experimental animals, with a view to effect 
its absorption. These experiments had also a negative result. 
It may likewise be stated that persons intentionally came from 
attending on sick animals and placed themselves in contact with 
the experimental cattle. Inoculations with the products of the 
disease, as obtained either from the lungs or the chest, have not 
been had recourse to, former experience having shown that such 
inoculations have invariably failed to transmit pleuro-pneumonia. 
Apart from natural cohabitation, it yet remains to be shown 
how the disease is conveyed from animal to animal in a herd. 
No safe deductions can, however, be drawn from th^se failures, 
for further experience may show that success may follow the 
repetition of one or more of the experiments. They possess, 
nevertheless, a certain value as illustrative of some of the reasons 
why pleuro-pneumonia often progresses so slowly among cattle 
lierded together ; and they also point to the propriety of isolating 
and slaughtering the first animal of a herd which becomes 
affected. These experiments will in due course be repeated, 
and others having the same object in view will be also adopted. 
Sheep-pox. — The importation of a cargo of sheep from Ham- 
burg, among which sheep-pox existed, led to the inoculation of 
an experimental sheep with the virus of this disease. The chief 
object being the production of a good pathological specimen, 
and even the death of the sheep, a very unusual quantity of the 
virus was employed and several punctures made in different parts 
of the body. Each of the punctures took, and on the eighth dav, 
as is usual, variolous fever set in. The intensity of the fever 
increased, and the skin gave evidence of a copious eruption, thus 
indicating that the object of the experiment would be obtained. 
For five or six days death was looked for ; at the end of this time, 
however, the severity of the symptoms began to abate and the 
animal ultimately recovered. Had the animal died, or a free 
vesication taken place on the skin, the solution of two problems 
might possibly have been effected : first, whether the infecting 
materies morhi contained in the contents of the vesicles could 
be easily destroyed by exposure to some of the supposed disin- 
fecting agents, recently advocated ; and secondly, whether placing 
