Inoculation for Anthrax and Quarter 111. 
461 
a telegram advising us of a case in the practice of Mr. Brett, 
M.R.C.V.S. of Mansfield, on November 23rd, Mr. Penberthy 
proceeded thither, informing Major Percy that he expected to 
be able to apply the test at Hodnet Hall on the following 
day. On arrival at Mansfield the animal was still alive and 
suffering from Quarter 111 ; but this being of a mild type 
and not likely to die immediately, we deemed it not quite 
satisfactory for so crucial a test. We determined to utilize this 
case for another purpose, and communicated our intention to 
Major Percy. By a happy coincidence preliminary signs of 
the disease were noticed in a heifer at a farm near Hodnet 
Hall, and being made aware of this fact by telegram, Mr. 
Penberthy started from Nottingham for Hodnet immediately. 
On arrival it was announced that, in addition to the heifer 
referred to, one of the experimental animals (uninoculated) A. 
was noticed lame at 4 . 30 P.M. ; at 9 . 30 P.M. we found it 
obviously dying of Quarter 111. Next morning at 6.30, A. was 
dead and cold, and at 11.20 A.M. the heifer first seized died. 
At 12 noon on the same day, in presence of a large number of 
gentlemen interested, the majority of whom had witnessed the 
inoculation on November 12th, Professor Penberthy injected, 
with all antiseptic precautions, into the subcutaneous tissue of 
the limbs of the remaining seven calves, a considerable quantity 
of virulent matter taken from the muscles of the still warm 
heifer. The seven were then placed and kept together in a 
meadow, under identical conditions. The table on page 462 is 
a register of the temperature taken twice daily. 
It will be borne in mind that A. uninoculated had died of 
the disease naturally contracted while grazing with the others. 
On the early morning of the 26th, C. was found so lame of 
the right hind limb that it could not walk. D. also was lame 
of the right hind limb. 
At 9 A.M. of the 27th, C. died, and Major Percy writes: 
" C. was opened in presence of several friends, and was proved 
to be a bad case of ' striking'" (Quarter 111), " spreading in all 
directions from point of inoculation." 
On the 28th D. appeared very stiff in both hind limbs, mostly 
the left ; he died at 10 A.M. on the 29th, and was opened in 
the presence of several farmers, and was also a clear case of 
striking," spreading on both sides from the point of inoculation. 
On the 28th a crepitating swelling Avas noticed on B.'s side 
at seat of inoculation ; she appeared very dull and unwell. On 
the 29th a " lump " was found at the above-named spot, and she 
was very unwell. On November 30th the swelling was hard 
and much more defined. It gradually softened on the subse- 
quent days, the calf returning to a state of health. 
