Report on Plcuro-Pneumonia and Foot-and-Mouth Disease. 205 
fully watched. No effects were observed, except slight primary 
swelling at the seat of inoculation. 
On the 3rd of November a good opportunity offered for the 
inoculation of a greater number of animals ; liquid of the same 
kind was used, and was injected into the circulation of three 
animals, viz., 2 two-year-olds and the yearling which previously 
had been inoculated in the cellular tissue and had continued 
throughout in perfect health. On the same day a cow was 
inoculated in the way ordinarily adopted for prophylactic pur- 
poses, viz., in the tail. In this case slight swelling and tender- 
ness ensued about the fourth day. The swelling increased very 
slowly up to the tenth day, after which it began to subside. But 
after the fourteenth day signs of softening appeared at the seat 
of the puncture, and eventually a small slough was formed which 
corresponded exactly with the line of puncture by the needle. 
Since that period the process has gone on in the neighbouring 
tissue, so that at present the end of the tail, from a little above 
the seat of the inoculation is undergoing slow necrosis. It is 
further to be noted that the swelling, up to the present time, has 
not extended to any distance from the seat of disease, and that 
the animal is still in perfect health and fair condition. 
On November 10th, a calf nearly two months old was inocu- 
lated by injection into the venous system, in the same way as 
has been already described. There was in this case some local 
reaction, lasting for over a week, a circumstance probably at- 
tributable to the greater difficulty of performing the injection 
without interfering with the tissues in the neighbourhood of 
the vein. There has, however, been no general disturbance 
of the system. 
Although I am not able to express an opinion as to the main 
question, it is worth while pointing out that the present ex- 
periments show in the most convincing manner, that not only 
subcutaneous inoculation with diseased material can be per- 
formed without danger, if the necessary precautions are used, 
but that the more serious operation of injecting pulmonary 
exudation liquid into the circulating blood, is not attended with 
any immediate results. 
FOOT-AND-MOUTH DISEASE. 
The experiments on Foot-and-Mouth Disease were begun early 
in June. In the order of dates they are as follows : 
1. On June 12th, two cows were inoculated with saliva, col- 
lected fresh from diseased animals at Deptford ; the mode of 
inoculation employed was by scarifying the gums. 
