on the Communication of Foot-and-Mmitli Disease. 461 
most important of these observations, particularly those relating 
to the infecting power of the discharge from the mouth. For 
this purpose material was obtained, not from infected cattle just 
imported from the Continent, but from animals in the Metro- 
politan Cattle Market, reported by the Inspector as affected with 
foot-and-mouth disease. 
As before, three of the experimental animals at the Brown 
Institution were fed, February 1st, 1877, with hay which was 
more or less soaked with the discharge from the mouths of the 
diseased animals. Subsequently, March 22nd, a fourth animal 
was treated in a similar manner. All of these acquired foot- 
and-mouth disease ; the time of incubation in the several cases 
being thirty-six hours, two days, two days, and three days, the 
first indication of the disease being afforded by the increase of 
bodily temperature. In each case the rise of temperature was 
followed after one day by the first appearance of the mouth 
eruption, which, twenty-four hours later, had assumed the vesi- 
cular form. 
The following Table exhibits the progress and duration of the 
disease : — 
Number 
of 
Animal. 
Temperature. 
Eruption. 
First Rise. 
Maximum 
Reached. 
Restoration to 
Normal. 
First 
Appearance. 
Full 
Development. 
i 
ir. 
in. 
IV. 
48 hours .. 
48 ~ .. 
3rd day .. 
36 hours .. 
4th day .. 
4th „ .. 
5th „ .. 
4th „ .. 
7th day .. 
7th „ .. 
8th „ .. 
Cth „ .. 
3rd day .. 
3rd „ .. 
4th „ .. 
3rd „ .. 
4 th day. 
4th 2 
5th , r 
4th „ 
The times stated in the Table are reckoned from the day on 
which the animals were fed on the soaked hay. 
The range of temperature was as follows : — 
K umber 
of 
Animal. 
Normal: 
First Rise. 
1 
Maximum. 
1 
I. 
II. 
III. 
IV. 
101-99 
101- 99 
102- 0 
101-55 
1U2-5 
102- 8 
103- 1 
102-2 
104- 8 
105- 2 
105-6 
104-5 
The restoration of the temperature to the normal might be 
evidently taken in this disease as a good sign of convalescence, 
