44 Report of a Series of Outbreaks of Splenic Apoplexy 
since the publication of my first experiments the subject has 
been attracting much attention in France, and quite recently a 
number of experiments have been published which afford a 
striking confirmation of my own results. These experiments, 
to which I shall on a future occasion refer in fuller detail, have 
also shown that the effects are largely modified by the breed of 
cattle on which the experiments are made; in fact, that the relative 
susceptibility of various breeds is very various, so that in the prac- 
tical application of any such method of preventive inoculation, 
what is good for French cattle does not necessarily hold good for 
English breeds. 
III. — Report of a Series of Outbreaks of Splenic Apoplexy on 
the Farm of Mr. J. R. Doggett, Holkliam, Norfolk. By J. 
WoRTLEY Axe, Professor of Pathology at the Royal Vete- 
rinary College. 
This Report refers to the prevalence of Splenic fever on certain 
marshes situated in the parish of Holkham, and now in the 
occupation of Mr. J. R. Doggett. The marshes in question 
form a part of the Earl of Leicester's estate. In consequence 
of a series of outbreaks of Anthrax among stock depastured there, 
I was requested, at the instigation of the Earl of Leicester, to 
visit Holkham, and institute a full inquiry into all the cir- 
cumstances relating to the malady. At the same time many 
important facts concerning former outbreaks, as well as the 
more recent ones, were furnished to me by Mr. Shellabear, his 
Lordship's agent. These, together with others collected on the 
spot, form the basis of the conclusions arrived at with regard to 
the origin of the disease at Holkham. With a view to the fur- 
nishing of data for future guidance in elucidating the precise 
conditions under which "splenic fever" is developed, I have 
deemed it advisable to record such meteorological facts as I 
could gather in reference to the periods to which the several 
outbreaks refer. For information on this point I am indebted 
to the kindness of Mr. Shellabear, who has afforded me much 
valuable assistance in the course of the inquiry. I may remark 
here that three distinct outbreaks occurring at intervals of three 
years are concerned in this Report. In reference to the two 
first, the amount of evidence obtained is necessarily small, owing 
to the length of time which has passed since their occurrence. 
Having, however, been drawn, in great part, from Mr. Doggett's 
diary, the data are known to be precisely accurate, and therefore 
of considerable value to the inquiry. 
