Prevention of Splenic Fever, S^'c, at the Broicn Institution. 307 
pervaded every inch of the lungs. The bronchial tubes, both 
large and small, were very much congested, and from them 
issued the froth. No part of the lungs heavier than water. 
Pleura slightly affected. 
" Heart. — Deposit of lymph in pericardium. Endocardium 
of right ventricle congested and livid, almost black. 
" Liver and Spleen of normal size, but darker in colour than 
usual. 
" Kidneys. — The left kidney very much congested, the right 
one healthy. 
" Intestines. — There were patches of inflammation over all 
the bowels and mesentery. 
" The Blood very dark and fluid," 
The condition of the lungs here described is, as I shall hope 
to show, of considerable interest in relation to some experi- 
ments which I made with the disease upon animals. The lung 
affection is evidently a marked and constant feature of the 
disease, and the principal conditions are subpleural exudation 
and a sort of bronchial catarrh. These I have been able to 
reproduce by inoculation of the disease in guinea-pigs and 
mice, with characters apparently almost identical with those 
seen in the original disease. Moreover, these lesions were in 
both situations attended with the presence of bacilli in the 
affected parts in the initial stages of the morbid process, disap- 
pearing as it reached its maximum. 
Of the original disease I have only had the opportunity of 
examining one specimen, a piece of the affected lung. This 
was not in a condition for examination for bacteria. The 
principal change was evidently an inflammation, slight in 
degree, which followed the lines of the bronchi, but in many 
places was evidently outside them. Some of the bronchi, espe- 
cially those of medium size, showed signs of catarrh, but there 
were a large number of which the mucous membrane appeared 
absolutely healthy. 
But in a large number of sections there were very marked 
changes around the vessels supplying the walls of the bronchi. 
Some of these were completely plugged by masses of leuco- 
cytes, and around them for some little distance were the 
ordinary appearances of inflammation. There were here and 
there patches of exudation, extending to close beneath the 
bronchial mucous membrane. 
The epithelial lining was in many of these perfectly healthy 
in appearance, but here and there the sub-mucous tissue con- 
siderably swollen and infiltrated. But the absence of bronchial 
catarrh was in most parts very striking ; only rarely was there 
any exudation in the air-cells. The pleura was thickened in 
scattered patches, apparently by exudation into its substance, 
X 2 
