308 Report on an Inquiry into the Nature, Causes and 
which was partly inflammatory, partly hsemorrhagic but no 
superficial effusion was observed. 
Let me anticipate what I shall have to say with regard to the 
results in rodents, for the sake of drawing a parallel between the 
condition here described and that found in them. In two mice, 
the one inoculated from the other, the first having been in- 
oculated from a guinea-pig, I found these changes. In the first, 
marked pulmonary congestion with slight subpleural exudation. 
In this lung I found commencing inflammation of the sub- 
pleural tissue with slight haemorrhagic exudation on the surface. 
Both in patches of the lung tissue, and in these deeper pleural 
layers and in the exudate I found here and there abundant 
bacilli, agreeing both with those cultivated from the peritoneal 
exudation and those seen in the other animals. Tliese were 
only found locally at the spots of commencing inflammation, and 
not elsewhere, except scattered in the lung. 
In the second animal there was no pleural exudation. I 
found, however, that in some of the larger bronchi, those near 
the root of the lung, there was incipient catarrh ; that this was 
not general, but limited to some parts of the circumference of 
the tube examined, and that side by side with affected bronchi 
were others absolutely healthy. 
Then I found that these affected parts corresponded with 
vessels which were the seat of commencing inflammation, and 
that around them in the tissues between them and the bronchi 
were long bacilli, corresponding exactly with those seen in 
the peritoneum, and in the lung and pleura of mouse No. 1. 
These bacilli one could trace passing through the walls of the 
vessels, and some were also seen in the blood within the ves- 
sels. As the inflammation began, they seemed to disappear, 
indicating the probability that inflammation is attended by their 
destruction. 
Similar bacilli were also found in the blood-vessels of the 
kidney, but I have as yet failed to find them in other 
organs. 
I may now describe these experiments. Some blood, which 
had been preserved in carefully filled capillary tubes, and some 
mucus from the nostrils were the materials used. The blood 
when examined was found to contain some spore-like bodies, a 
few remains of short rods, and also a few micrococci. A 
guinea-pig which was inoculated with the blood died in 
seventeen hours. When examined, four hours after death, there 
was very slight inflammation and serous exudation at the sekt 
of inoculation, the heart was filled with coagula, the organs 
generally appeared natural. The blood contained numerous 
rods and also free spores ; that taken from the heart containing 
the greatest abundance, more than the splenic blood. 
