A NEW WHITE-LOCK FAMILY (BARTON'S CASE). 
By KARL PEARSON, F.R.S. 
The hereditary nature of the " flare " — or pigmentless forehead patch accom- 
panied by a white or yellow white-lock of hair — in man is now well known. Several 
illustrative pedigrees were published by Nettleship, Usher and Pearson in their Mono- 
graph on Albinism*, and a good pedigree was also published by Dr E. A. Cockayne 
in 1914 under the title of " A Piebald Familyf." That family embraced six gene- 
rations of the hereditary flare. In the present case we have only been able to trace 
four generations with a total of seven affected members. Dr Cockayne's pedigree 
involved nineteen affected members, while Rizzoli's pedigree of the Bianconcini 
family extends to six generations with twenty affected members. I owe the case to 
Dr E. R. Barton, of University College Hospital, who came across III. 1 and IV. 10 
in the Midwifery Department of the hospital and most courteously put me in touch 
with the family. The pedigree should accordingly be referred to under Dr Barton's 
name. 
There is no consanguinity. The family goes grey early and there has been a 
certain amount of tuberculosis. 
No consanguinity. + Died at birth 
1. 1. T. H. Normal, died at about 40. 
I. 2. J. F. Married 1. 1 and is the earliest known ascendant to have the flare. 
She had both white forehead patch and white lock. She died at about 80. 
* A Monograph on Albinism in Man, Part I, p. 254, Cambridge University Press, 
t Biometrika, Vol. x. pp. 197 — 200, with eight plates. 
