43 
centers could be used for purchase of land, architectural fees, and con- 
struction costs. They could not be used for operational costs. The per- 
formance of construction had to comply with a number of conditions. It was 
the responsibility of the grantee (host) institution to supervise and inspect 
the construction in progress and to determine when the construction had been 
completed in compliance with the conditions, to accept the completed facility, 
and to make final payment to the contractor. Inspection visits could also 
be made by members of the National Advisory Heart Council and the NHI staff. 
The grantee institution had to keep appropriate accounting records suitable 
for audit and to provide the granting agency (NHI) with the necessary expen- 
diture report(s). Construction grant funds were released to the grantee 
institution, upon appropriately timed requests, in suitable installment pay- 
ments as construction progressed. At least 5 percent of the grant funds were 
withheld by the granting agency to satisfy any possible claims or adjustments 
at the final audit. Upon completion of construction and acceptance by the 
grantee institution, inspection of the primate research facility could be made 
by the Surgeon General of the PHS or his representative(s) . 
To assist in the handling of the construction aspects of the Regional Primate 
Research Center program, Dr. Eyestone called upon the services of the intramural 
NIH architects and added an architect-engineer to his staff. Although, for 
one reason or another, some of the construction took longer than was at first 
anticipated, the program moved along without particular difficulty. The first 
construction began in 1960 in Portland, Oregon, and the last was finished at 
Davis, Calif ornia^ in 1966, In practically all of the centers, investigative 
programs began prior to completion. 
B. Operation of Centers 
Operational grants to the centers are subject to the PHS regulations for research 
project grants-^', to the extent that they apply^' . In line with the initial 
agreements made before each grant was awarded-^ , every center director was to 
have a scientific advisory board including member scientists with broad ex- 
perience in a variety of disciplines from various parts of the country. The 
board members, who were to be selected and appointed by the host institution 
(the principal investigator being responsible), would meet at the center at 
Tj Title 42, Chapter I, Subchapter D, Part 52. 
An informal policy guide was developed in 1963 to supplement the regulations 
for research project grants and has been used as a guide in the operation of 
the program. 
2/ "Statement of Responsibilities and Relationships." 
