of plasma endothelin- 1 concentration in normal 
and hypenensive subjects. Am Heart J 123: 
1092-1093. 
Sakurai, T., Yanagisawa, M., Inoue, A., Ryan, U.S., 
Kimura, S., Mitsui, Y., Goto, K., and Masaki, T. 
1991. cDNA cloning, sequence analysis and tissue 
distribution of rat preproendothelin- 1 mRNA. 
Biochem Biophys Res Commun 175:44-47. 
Sawamura, T., Kasuya, Y., Matsushita, Y., Suzuki, N., 
Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, 
M., Goto, K., Masaki, T., and Kimura, S. 1991. 
Phosphoramidon inhibits the intracellular con- 
version of big endothelin- 1 to endothelin- 1 in 
cultured endothelial cells. Biochem Biophys Res 
Commun 174:779-784. 
Shichiri, M., Hirata, Y., Nakajima, T., Ando, K., Imai, 
T., Yanagisawa, M., Masaki, T., and Marumo, F. 
1991. Endothelin- 1 is an autocrine/paracrine 
growth factor for human cancer cell lines. / C/m 
Invest SI 
Shigeno, T., Mima, T., Yanagisawa, M., Saito, A., 
Goto, K., Yamashita, K., Takenouchi, T., Mat- 
suura, N., Yamasaki, Y., and Yamada, K. 1991. 
Prevention of cerebral vasospasm by actinomycin 
D. J Neurosurg 74:940-943. 
Stelzner, T.J., O'Brien, R.F., Yanagisawa, M., Sa- 
kurai, T., Sato, K., Webb, S., Zamora, M., 
McMurtry, I.E., and Eisher, J.H. 1992. Increased 
lung endothelin- 1 production in rats with idio- 
pathic pulmonary hypertension. Am J Physiol 
262:L614-L620. 
Tomobe, Y., Ishikawa, T., Yanagisawa, M., Ki- 
mura, S., Masaki, T., and Goto, K. 1991. Mecha- 
nisms of altered sensitivity to endothelin- 1 be- 
tween aortic smooth muscles of spontaneously 
hypertensive and Wistar-Kyoto rats. J Pharmacol 
Exp Ther 251 -.555-561. 
Toyo-oka, T., Aizawa, T., Suzuki, N., Hirata, Y., 
Miyauchi, T., Shin, W.S., Yanagisawa, M., Ma- 
saki, T., and Sugimoto, T. 1991 . Increased plasma 
level of endothelin- 1 and coronary spasm induc- 
tion in patients with vasospastic angina pectoris. 
Circulation 83:476-483. 
Watanabe, M., Yanagisawa, M., Hamaguchi, H., 
Kanazawa, 1., and Masaki, T. 1991 . Taql polymor- 
phism at the human preproendothelin- 1 gene 
(EDNl). Nucleic Acids Res 19:5099- 
Yokokawa, K., Tahara, H., Kohno, M., Murakawa, K., 
Yasunari, K., Nakagawa, K., Hamada, T., Otani, S., 
Yanagisawa, M., and Takeda, T. 1991. Hyper- 
tension associated with endothelin-secreting ma- 
lignant hemangioendothelioma. Ann Intern Med 
114:213-215. 
CELL BIOLOGY AND REGULATION 
127 
