Books and Chapters of Books 
Chandrasekharappa, S.C., Marchuk, D.A., and Col- 
lins, F.S. 1992. Analysis of yeast artificial chro- 
mosome clones. In Methods in Molecular 
Biology: Pulsed Field Gel Electrophoresis Tech- 
niques (Walker, J., Ed.). Totowa, NJ: Humana, vol 
12, pp 235-257. 
Collins, F.S., and lannuzzi, M.C. 1992. Genetic de- 
fect in cystic fibrosis. In Update: Pulmonary Dis- 
eases and Disorders (Fishman, A.P., Ed.). New 
York: McGraw-Hill, pp 83-92. 
Gumucio, D.L., Blanchard-McQuate, K.L., 
Heilstedt-Williamson, H., Tagle, D.A., Gray, T.A., 
Tarle, S.A., Gragowski, L., Goodman, M., 
Slightom, J., and Collins, F.S. 1991. 7-globin 
gene regulation: evolutionary approaches. In The 
Regulation of Hemoglobin Switching (Sta- 
matoyannopoulos, G., and Nienhuis, A.W., Eds.). 
Baltimore, MD: Johns Hopkins University Press, 
pp 277-289. 
Articles 
Andersen, L.B., Wallace, M.R., Marchuk, D.A., Ta- 
vakkol, R., Mitchell, A.L., Saulino, A.M., and Col- 
lins, F.S. 1991. A highly polymorphic cDNA 
probe in the NFl gene. Nucleic Acids Res 
19:3754. 
Basu, T.N., Gutmann, D.H., Fletcher, J.A., Glover, 
T.W., Collins, F.S., and Downward, J. 1992. 
Aberrant regulation of ras proteins in malignant 
tumour cells from type 1 neurofibromatosis pa- 
tients. Nature 356:713-715. 
Bates, G.P., Valdes, J., Hummerich, H., Baxendale, 
S., LePaslier, D.L., Monaco, A.P., Tagle, D., Mac- 
Donald, M.E., Altherr, M., Ross, M., Brownstein, 
B.H., Bentley, D , Wasmuth, J.J., Gusella, J.F., Co- 
hen, D., Collins, F.S., and Lehrach, H. 1992. 
Characterization of a yeast artificial chromosome 
contig spanning the Huntington's disease gene 
candidate region. Nature Genet 1:180-187. 
Biesecker, L., Bowles-Biesecker, B., Collins, F.S., 
Kaback, M., and Wilfond, B. 1992. General popu- 
lation screening for cystic fibrosis is premature 
[letter]. Am J Hum Genet 50:438-439- 
Collins, F.S. 1991. Identification of disease genes: 
recent successes. Hosp Pract 26:93-98. 
Collins, F.S. 1991. Identification of the type 1 
neurofibromatosis gene. Neurosci Forum 1:5. 
Collins, F.S. 1991. Medical and ethical conse- 
quences of the Human Genome Project. / Clin 
Ethics 2:260-267. 
Collins, F.S. 1991. Of needles and haystacks: find- 
ing human disease genes by positional cloning. 
Clin Res 39:615-623. 
Collins, F.S. 1992. Cystic fibrosis: molecular biol- 
ogy and therapeutic implications. Science 256: 
774-779. 
Collins, F.S. 1992. Physician-scientists: a vanishing 
breed. Yale Med ¥^\\/Wmtev.5-S. 
Collins, F.S. 1992. Positional cloning: Let's not call 
it reverse anymore. Nature Genet 1:3-6. 
Drumm, M.L., Wilkinson, D.J., Smit, L.S., Worrell, 
R.T., Strong, T.V., Frizzell, R.A., Dawson, D.C., 
and Collins, F.S. 1991. Chloride conductance 
expressed by AF508 and other mutant CFTRs in 
Xenopus oocytes. Science 254:1797-1799- 
Gibson, A.L., Wagner, L.M., Collins, F.S., and Ox- 
ender, D.L. 1991- A bacterial system for investi- 
gating transport effects of cystic fibrosis-asso- 
ciated mutations. Science 254:109-1 1 1- 
Goldberg, N.S. , and Collins, F.S. 1 99 1 - The hunt for 
the neurofibromatosis gene. Arch Dermatol 
127:1705-1707. 
Gumucio, D.L., Rood, K.L., Blanchard-McQuate, 
K.L., Gray, T.A., Saulino, A.M., and Collins, F.S. 
1991. Interaction of Sp 1 with the human 7 globin 
promoter: binding and transactivation of normal 
and mutant promoters. Blood 78:1853-1863. 
Gusella, J.F., Altherr, M.R., McClatchey, A.I., 
Doucette-Stamm, L.A., Tagle, D., Plummer, S., 
Groot, N., Collins, F.S., Housman, D.E., Lehrach, 
H., MacDonald, M.E., Bates, G., and Wasmuth, J.J. 
1992. Sequence-tagged sites (STSs) spanning 
4pl6.3 and the Huntington disease candidate re- 
gion. Genomics 13:75-80. 
Gutmann, D.H., and Collins, F.S. 1992. Recent 
progress toward understanding the molecular bi- 
ology of von Recklinghausen neurofibromatosis. 
Ann Neurol 1:555-561. 
Gutmann, D.H., Wood, D.L., and Collins, F.S. 
199I- Identification of the neurofibromatosis 
type 1 gene product. Proc Natl Acad Sci USA 
88:9658-9662. 
Kainulainen, K., Steinmann, B., Collins, F.S., Dietz, 
H.C., Francomano, C.A., Child, A., Kilpatrick, 
M.W., Brock, D.J.H., Keston, M., Pyeritz, R.E., and 
Peltonen, L. 1991- Marfan syndrome: no evidence 
for heterogeneity in different populations, and 
more precise mapping of the gene. Am J Hum 
Genet i9 -.662-661 . 
Krauss, R-D., Bubien, J.K., Drumm, M.L., Zheng, T., 
Peiper, S.C., Collins, F.S., Kirk, K.L., Frizzell, 
R.A., and Rado, T.A. 1992. Transfection of wild- 
type CFTR into cystic fibrosis lymphocytes re- 
stores chloride conductance at Gj of the cell cy- 
cle. EMBO J 1 1 :875-883. 
MacDonald, M.E., Novelletto, A., Lin, C, Tagle, D., 
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