peated dinucleotide or tetranucleotide sequences 
and unique flanking sequences. Because their se- 
quences are known, STS markers can bridge the 
gaps between genetic and physical maps of 
chromosomes. 
New genetic maps for chromosomes 13, 17, and 
20, containing STSs and other markers, have been 
submitted for publication. Physical mapping in 
chromosomal regions of interest is also under way. 
For example, Dr. Hans Albertsen has identified more 
than 30 YACs (yeast artificial chromosomes) from a 
region of chromosome 17 believed to contain an 
inherited gene for premenopausal breast cancer. 
Dr. White is also Thomas D. Dee II Professor of 
Human Genetics and Adjunct Professor of Cellu- 
lar, Viral, and Molecular Biology at the University 
of Utah School of Medicine. 
Books and Chapters of Books 
Leppert, M., Anderson, V.E., and White, R. 1991. 
The discovery of epilepsy genes by genetic link- 
age. In Genetic Strategies in Epilepsy Research 
(Anderson, V.E., Hauser, W.A., Leppik, I.E., Noe- 
bels, J.L., and Rich, S.S., Eds.). New York: Else- 
vier, pp 181-188. 
White, R. 1991. Identification of the neurofibro- 
matosis gene. In Origins of Human Cancer: A 
Comprehensive Review (Brugge, J., Curran, T., 
Harlow, E., and McCormick, F., Eds.). Plainview, 
NY: Cold Spring Harbor, pp 623-632. 
White, R. 1992. The neurofibromatosis gene. In 
Neuroscience Year: Supplement 2 to the Ency- 
clopedia of Neuroscience (Smith, B., and Adel- 
man, G., Eds.). Boston, MA: Birkhauser, pp 112- 
114. 
Articles 
Dumanski, J. P., Carlbom, E., Collins, V.P., Nor- 
denskjold, M., Emanuel, B.S., Budarf, M.L., 
McDermid, HE., Wolff, R., O'ConneU, P., 
White, R., Lalouel,J.-M., and Leppert, M. 1991. 
A map of 22 loci on human chromosome 22. Ge- 
nomics 1 1:709-719. 
Keating, M., Dunn, C, Atkinson, D., Timothy, K., 
Vincent, G.M., and Leppert, M. 1991 . Consistent 
linkage of the long-QT syndrome to the Harvey 
ras- 1 locus on chromosome 1 1 . Am f Hum Genet 
49:1335-1339. 
Li, Y., Bollag, G., Clark, R., Stevens, J., Conroy, L., 
Fults, D., Ward, K., Friedman, E., Samowitz, W., 
Robertson, M., Bradley, P., McCormick, F., 
White, R., and Cawthon, R. 1992. Somatic muta- 
tions in the neurofibromatosis 1 gene in human 
tumors. Ce// 69:275-281. 
Lynch, S., Rose, J.W., Petajan, J.H., Stauffer, D., Ka- 
merath, C, and Leppert, M. 1991. Discordance 
of T-cell receptor |8-chain genes in familial multi- 
ple sclerosis. Ann Neurol 30:402-410. 
Matsunami, N., Smith, B., Ballard, L., Lensch, 
M.W., Robertson, M., Albertsen, H., Hanemann, 
CO., Muller, H.W., Bird, T.D., White, R., and 
Chance, P.F. 1992. Peripheral myelin protein-22 
gene maps in the duplication in chromosome 
17pll.2 associated with Charcot-Marie-Tooth 
lA. Nature Genet 1:176-179. 
Mitchell, A., Bale, A.E., Wang-ge, M., Yi, H.F., 
White, R., Pirtle, R.M., andMcBride, O.W. 1991. 
Localization of a DNA segment encompassing four 
tRNA genes to human chromosome l4ql 1 and its 
use as an anchor locus for linkage analysis. Ge- 
nomics 11:1063-1070. 
Ptacek, L.J., George, A.L., Jr., Griggs, R.C., Tawil, R., 
Kallen, R.G., Barchi, R.L., Robertson, M., and 
Leppert, M.F. 1991. Identification of a mutation 
in the gene causing hyperkalemic periodic paraly- 
sis. Ce// 67:1021-1027. 
Ptacek, L.J., Trimmer, J.S., Agnew, W.S., Roberts, 
J.W., Petajan, J.H., and Leppert, M. 1991. Para- 
myotonia congenita and hyperkalemic periodic 
paralysis map to the same sodium-channel gene 
locus. Am f Hum Genet 49:851-854. 
Ptacek, L.J., Tyler, F., Trimmer, J.S., Agnew, W.S., 
and Leppert, M. 1991 . Analysis in a large hyper- 
kalemic periodic paralysis pedigree supports 
tight linkage to a sodium channel locus. Am f 
Hum Genet 49:578-582. 
Spirio, L., Joslyn, G., Nelson, L., Leppert M., and 
White, R. 1991. A CA repeat 30-70 kb down- 
stream from the adenomatous polyposis coli 
(APC) gene. Nucleic Acids Res 19:6348. 
Spirio, L., Otterud, B., Stauffer, D., Lynch, H., 
Lynch, P., Watson, P., Lanspa, S., Smyrk, T., Cava- 
lieri, J., Howard, L., Burt, R., White, R., and Lep- 
pert, M. 1992. Linkage of a variant or attenuated 
form of adenomatous polyposis coli to the ade- 
nomatous polyposis coli (APC) locus. Am f Hum 
Genet 51:92-100. 
Takahashi, E., Hori, T., O'ConneU, P., Leppert, M., 
and White, R. 1 99 1 . Mapping of the MYC gene to 
band 8q24.12-^q24.13 by R-banding and distal 
to fra(8)(q24.1 1), FRA8E, by fluorescence in 
situ hybridization. Cytogenet Cell Genet 57: 
109-111. 
White, M.B., Leppert, M., Nielsen, D., Zielenski, J., 
Gerrard, B., Stewart, C, and Dean, M. 1991. A 
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