an average of 800 kb each have thus far been identi- 
fied for a 27-Mb region (q22-q31) where specific 
translocation and deletion breakpoints are fre- 
quently found in leukemic cells. In addition to gen- 
eration of a long-range physical map of chromosome 
7, efficient techniques are being developed for de- 
tecting gene sequences based on YAC cloning. 
Dr. Tsui is Senior Scientist and Sellers Chair of 
Cystic Fibrosis Research in the Department of Ge- 
netics at the Research Institute of the Hospital for 
Sick Children, Toronto, and Professor of Molecu- 
lar and Medical Genetics at the University of 
Toronto. 
Articles 
Chou, J.L. , Rozmahel, R. , and Tsui, L.-C. 1991. Char- 
acterization of the promoter region of the cystic 
fibrosis transmembrane conductance regulator 
gene, f Biol Chem 266:24471-24476. 
Kristidis, P., Bozon, D., Corey, M., Markiewicz, D., 
Rommens, J., Tsui, L.-C, and Durie, P. 1992. Ge- 
netic determination of exocrine pancreatic func- 
tion in cystic fibrosis. Am f Hum Genet 50: 
1178-1184. 
Rommens, J.M., Dho, S., Bear, C.E., Kartner, N., 
Kennedy, D., Riordan, J.R., Tsui, L.-C, and Fos- 
kett,J.K. 1991- cAMP-inducible chloride conduc- 
tance in mouse fibroblast lines stably expressing 
the human cystic fibrosis transmembrane conduc- 
tance regulator. Proc Natl Acad Sci USA 88: 
7500-7504. 
Scherer, S.W., Otulakowski, G., Robinson, B.H., and 
Tsui, L.-C 1991 . Localization of the human dihy- 
drolipoamide dehydrogenase gene (DLD) to 
7q31-q32. Cytogenet Cell Genet 5<S:\l6-\ll . 
Scherer, S.W., Thompkins, B.J.F., and Tsui, L.-C. 
1992. A human chromosome 7-specific genomic 
DNA library in yeast artificial chromosomes. 
Mamm Genome 3:179-181. 
Tsui, L.-C. 1991. Probing the function of cystic fi- 
brosis transmembrane conductance regulator. 
Curr Opin Genet Dev 1:4-10. 
Tsui, L.-C, and Buchwald, M. 1991. Biochemical 
and molecular genetics of cystic fibrosis. Adv 
Hum Genet 20:155-266, 311-312. 
Tsui, L.-C, Rommens, J., Kerem, B., Rozmahal, R., 
Zielenski, J., Kennedy, D., Markiewicz, D., Plav- 
sic, N., Chou, J.-L., Bozon, D., and Dobbs, M. 
1991. Molecular genetics of cystic fibrosis. Adv 
Exp Med Biol 290:9-17. 
Zielenski, J., Markiewicz, D., Rininsland, F., Rom- 
mens, J. , and Tsui, L.-C 1 99 1 . A cluster of highly 
polymorphic dinucleotide repeats in intron 17b 
of the cystic fibrosis transmembrane conductance 
regulator (CFTR) gene. Am f Hum Genet 49: 
1256-1262. 
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