Molecular Mechanisms of Tissue -Specific Hormonal 
Regulation of Gene Expression 
Studies on the regulation of IRP-A gene expres- 
sion have led to an understanding of the mecha- 
nism by which insulin modulates the expression 
of specific genes in specific tissues involved in 
the maintenance of normal glucose and lipid me- 
tabolism. Ultimately these studies will lead to an 
understanding of the signal transduction process 
by which insulin modulates the expression of 
these genes. Understanding the hormonal control 
of lipid metabolism at a molecular level will pro- 
vide insights into two disease states of major im- 
portance, obesity and diabetes. 
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