i 
Cultured epidermal cells from a transgenic mouse expressing a mutant keratin gene. The cells 
were stained with an antibody specific to the mutant keratin protein. Note the presence of small 
balls, or aggregates, at the ends of the filaments. These structures are aberrancies in the filament 
network caused by the presence of the mutant keratin. 
Research of Elaine V. Fuchs. 
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