DNA-seqtiencing Technologies 
range of a few thousand molecules is achieved 
and all four bases can be detected in the output 
from one column. Charge-coupled devices 
(CCDs) are ideal for detection of these low-fluor- 
escent signals and permit spatial resolution that 
will be helpful for continuous spectral analysis 
and for parallel analysis of multiple capillaries. 
Commercial instruments for conventional 
zone capillary electrophoresis have worked out 
automated sample-handling that can be adapted 
to the sequencing problem. We see these auto- 
mated and multiplexed capillary sequencing in- 
struments as potential alternatives to current fluo- 
rescent machines for primer-based sequencing. 
We have been struck by the interest that col- 
leagues in more engineering-related sciences 
have shown in these problems. The project 
has resulted in a refreshing blend of interests 
that will bring new solutions to molecular 
investigations. 
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